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Book Cover
Author Aptsiauri, Natalia

Title MHC class I antigens in malignant cells : immune escape and response to immunotherapy / Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera
Published New York, NY : Springer, ©2013


Description 1 online resource
Series SpringerBriefs in cancer research ; 6
SpringerBriefs in cancer research ; 6.
Contents Overview of MHC Class I Antigens -- HLA Class I Expression in Human Cancer -- MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns -- Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression -- Conclusions
Summary Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develo
Analysis Medicine
Cancer Research
Molecular Medicine
Bibliography Includes bibliographical references
Subject Cancer -- Immunological aspects.
Major histocompatibility complex.
HLA histocompatibility antigens.
HLA class II antigens.
Neoplasms -- immunology
Major Histocompatibility Complex
Histocompatibility Antigens Class II
HEALTH & FITNESS -- Diseases -- Cancer.
MEDICAL -- Oncology.
HLA class II antigens
Cancer -- Immunological aspects
HLA histocompatibility antigens
Major histocompatibility complex
Form Electronic book
Author Garcia-Lora, Angel Miguel
Cabrera, Teresa
ISBN 9781461465430