| Description |
1 online resource |
| Contents |
Historical overview / R. David -- MIF "rediscovered" / R. Bucala -- Immunopathologic mechanisms relevant to diseases / H.Y. Lan -- Structural studies of MIF / E. Lolis -- MIF redox activity / J. Bernhgaen -- MIF receptor-mediated signal transduction / C. Leng -- MIF in innate immunity and infectious diseases / T. Calandra -- MIF in parasitic and helminth infections / A.R. Satoskar -- MIF in the pathogenesis of kidney disease / R.C. Atkins -- MIF and CNS autoimmune disease / T.G. Forsthuber -- MIF: wound repair / G.S. Ashcroft -- MIF and atherosclerosis / C. Weber -- Inflammatory arthritis / E. Morand -- MIF alleles in infammatory arthritis / R. Donn -- Adhesion-dependent signaling and growth control / R. Mitchell |
| Summary |
In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high- |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Macrophage migration inhibitory factor.
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Macrophage Migration-Inhibitory Factors
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MEDICAL -- Immunology.
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Macrophage migration inhibitory factor.
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| Form |
Electronic book
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| Author |
Bucala, Richard
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| ISBN |
9812775919 |
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9789812775917 |
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