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Title Structural bioinformatics / edited by Philip E. Bourne, Helge Weissig
Published Hoboken, N.J. : Wiley-Liss, [2003]


Location Call no. Vol. Availability
 W'PONDS  572.8733 Bou/Sbi  AVAILABLE
Description xix, 649 pages, 32 unnumbered pages of plates : illustrations (some color) ; 26 cm
Series Methods of biochemical analysis ; v. 44
Methods of biochemical analysis ; v. 44
Contents Section 1. Introduction. Defining bioinformatics and structural bioinformatics / R. Altman & J. Dugan. Fundamentals of protein structure / E. Scheeff & L. Fink. Fundamentals of DNA and RNA structure / S. Neidle ... [et al.]. Computational aspects of high-throughput crystallographic macromolecular structure determination / P. Adams ... [et al.]. Macromolecular structure determination by NMR spectroscopy / J. Markley ... [et al.]. Electron microscopy / N. Volkmann & D. Hanein. Molecular visualization / J. Tate -- Section 2. Data representation and databases. The PDB format, mmCIF formats, and other data formats / J. Westbrook & P. Fitzgerald. The protein data bank / The PDB Team. The nucleic acid database / H. Berman ... [et al.]. Other structure-based databases / H. Weissig & P. Bourne -- Section 3. Comparative features. Protein structure evolution and the SCOP database / B. Reddy & P. Bourne. The CATH domain structure database / C. Orengo ... [et al.]. Structural quality assurance / R. Laskowski. All-atom contacts: a new approach to structure validation / J. Richardson. Structure comparison and alignment /P. Bourne & I. Shinadyalov. -- Section 4. Structure and functional assignment. Secondary structure assignment / C. Andersen & B. Rost. Identifying structural domains in proteins / L. Wernisch & S. Wodak. Inferring protein function from structure / G. Bartlett ... [et al.] -- Section 5. Protein interactions. Prediction of protein-protein interactions from evolutionary information / A. Valencia & F. Pazos. Electrostatic interactions / N. Baker & J. McCammon. -- Section 6. Proteins as drug targets. Principles and methods of docking and ligand design / J. Krumrine ... [et al.]. Structural bioinformatics in drug discovery / E. Fauman ... [et al.] -- Section 7. Structure prediction. CASP and CAFASP experiments and their findings / P. Bourne. Homology modeling / E. Krieger ... [et al.]. Fold recognition methods / A. Godzik. Ab initio methods / D. Chivian ... [et al.]. Prediction in 1D: secondary structure, membrane helices, and accessibility / B. Rost -- Section 8. The future. Structural genomics / S. Burley & J. Bonanno
Summary "The emerging discipline of structural bioinformatics comprises the development of computational technologies for methods of storage, retrieval, and analysis of the three-dimensional structure of biological macromolecules. Edited by Philip Bourne and Helge Weissig, this groundbreaking text provides a thorough understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics." "Readers will gain the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Molecular biologists, biochemists, biophysicists, and bioinformaticians in basic and clinical research, as well as undergraduate and graduate students in biology, medicine, and computer science, will find Structural Bioinformatics to be an essential addition to their professional and academic libraries."--BOOK JACKET
Bibliography Includes bibliographical references and index
Notes English
Subject Macromolecules -- Structure -- Computer simulation.
Macromolecules -- Structure -- Mathematical models.
Computational Biology.
Author Bourne, Philip E.
Weissig, Helge.
LC no. 2002011156
ISBN 0471202002 cloth alkaline paper
0471201995 paperback