| Description |
1 online resource (xiv, 453 pages, 2 unnumbered pages of plates) : illustrations (some color) |
| Series |
Progress in molecular biology and translational science ; v. 98 |
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Progress in molecular biology and translational science ; v. 98.
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| Contents |
Front Cover; Progress in Molecular Biology and Translational Science: The Brain as a Drug Target; Copyright; Contents; Contributors; Preface; Chapter 1: Monoamine Transporters: Vulnerable and Vital Doorkeepers; I. Introduction; II. Clinical Benefits: Demonstration of the Medical Roles of Monoamine Transporters; III. Preclinical Indications-Behavioral Pharmacology; IV. Molecular Study: cDNA Cloning and Structure Activity Relationship; V. Protein Regulations; VI. Animal Genetics; VII. The Transporter Genes as Risk Factors; VIII. Perspectives for Medication Development; Acknowledgments |
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VI. Future Directions for Optimization of Treatment RegimensReferences; Chapter 4: Insulin, Synaptic Function, and Opportunities for Neuroprotection; I. Introduction; II. Insulin Within the Central Nervous System; III. Insulin Receptors Within the Brain; IV. Insulin Signaling and Synaptic Function; V. Therapeutic Opportunities: Insulin and Neuroprotection; VI. General Summary; References; Chapter 5: Molecular Alterations in Glioblastoma: PotentialTargets for Immunotherapy; I. Introduction; II. Genetic Alterations in Glioblastoma; III. Ags and Biomarkers in Glioblastoma |
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IV. Ag-Specific Immunotherapy for GlioblastomaV. Biomarker-Specific Chemotherapy for Glioblastoma; VI. Cytokine-Based Immunotherapy for Glioblastoma; VII. Chemoimmunotherapy for Glioblastoma; VIII. Tumor-Associated Molecules Influencing Glioblastoma Immunotherapy; IX. Conclusions; Acknowledgments; References; Chapter 6: Molecular Signaling and Translational Significance of the Corticotropin Releasing Factor System; I. Introduction to the Corticotropin Releasing Factor Peptide Family; II. Neural CRF Distribution; III. CRF Binding and Signal Transduction |
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IV. Genes and Gene Systems Activated by CRFV. Interactions with Other Neural Circuits; VI. Translational Significance of CRF; VII. Integrated CRF Function; References; Chapter 7: Molecular Targets of Alcohol Action: Translational Research for Pharmacotherapy Development and Screening; I. Introduction; II. Alcohol Abuse and Dependence, Significance, and Treatment Needs; III. Preclinical Strategies for Identification of Novel Targets of Alcohol Action; IV. Translational Strategies and Need for Continued Biomarkers Development; References |
| Summary |
The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This volume discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Text in English |
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Print version record |
| Subject |
Psychotropic drugs.
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Brain -- Effect of drugs on
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Brain -- Diseases -- Treatment
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Brain -- Wounds and injuries -- Treatment
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Psychotropic Drugs
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MEDICAL -- Pain Medicine.
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MEDICAL -- Psychiatry -- Psychopharmacology.
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Brain -- Diseases -- Treatment
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Brain -- Effect of drugs on
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Brain -- Wounds and injuries -- Treatment
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Psychotropic drugs
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| Form |
Electronic book
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| Author |
Rahman, Shafiqur, 1963- editor.
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| ISBN |
9780123855077 |
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0123855071 |
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9780123855060 |
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0123855063 |
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1282968890 |
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9781282968899 |
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9786612968891 |
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6612968893 |
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