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Title Biological and clinical landscape of meningiomas / Gelareh Zadeh, Roland Goldbrunner, Boris Krischek, Farshad Nassiri, editors
Published Cham, Switzerland : Springer, [2023]


Description 1 online resource (xvii, 255 pages)
Series Advances in experimental medicine and biology ; volume 1416
Advances in experimental medicine and biology ; v. 1416.
Contents Paradigm Shift in the Treatment of Meningiomas -- Clinical Presentation and Prognosis -- Imagining characteristics of meningiomas -- Histopathology of Meningiomas -- Skull Base Meningiomas -- Spinal Meningiomas -- Surgical Therapy of Non-Skull Base Meningiomas -- Radiotherapy for Meningioma -- Stereotactic Therapies for Meningiomas -- Advances in Central Nervous System Tumor Classification -- Genomic Landscape of Meningiomas -- Radiation-Induced Meningiomas -- The Epigenetic Landscape of Meningiomas -- Immune Profiling of Meningiomas -- Preclinical Models of Meningioma -- Novel Medical Therapies in Meningiomas -- Immunotherapy for Meningiomas -- Health-Related Quality of Life in Intracranial Meningioma: Current Evidence and Future Directions
Summary "Meningiomas are tumors that originate from the arachnoidal cap cells of the leptomeninges. With an incidence rate of 8.36 per 100, 000 population, they are the most common primary central nervous system (CNS) tumors, accounting for a third of all cases. The World Health Organization (WHO) classification has traditionally categorized meningiomas into 15 different histopathological subtypes and three clinical grades. Tumors are classified as WHO grades 1, 2 or 3 based largely on histopathological features such as mitotic activity, presence of brain invasion, and other atypical features. However, there is increasing recognition of the limitations of histopathology including but not limited to: confounding factors such as sampling bias in a heterogeneous tumor, and technical factors related to the experience of the grading pathologist. Even with careful histologic grading, there remains significant variability in recurrence rates within each tumor grade. As more studies have uncovered the molecular features of meningiomas, novel biological alterations have helped refine classification schemes that more accurately reflect patient outcomes. This book reviews the current state of knowledge on the genomic and epigenomic landscape of meningiomas in order to identify the roles of genomic aberrations on diagnosis, prognosis, and treatment of meningiomas in addition to mainstays of surgical management, radiation therapy, and potential novel chemotherapies. Written by a team of world-renowned experts in neurosurgery, neuropathology, radiology, and radiation-oncology, this book is the definitive resource on meningioma management and investigation for both clinicians and scientists alike."
Notes Includes index
Description based on online resource; title from digital title page (viewed on October 06, 2023)
Subject Meningioma.
Form Electronic book
Author Zadeh, Gelareh, editor.
Goldbrunner, Roland, editor.
Krischek, Boris, 1972-2021, editor.
Nassiri, Farshad, editor.
ISBN 9783031297502