| Description |
1 online resource |
| Series |
Advances in experimental medicine and biology ; volume 1416 |
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Advances in experimental medicine and biology ; v. 1416.
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| Contents |
Intro -- Foreword -- Acknowledgments -- Contents -- About the Contributors -- Paradigm Shift in the Treatment of Meningiomas -- 1 Treatment Timeline -- 2 Epidemiology -- 3 Treatment -- 4 Histology, Grading, and Molecular Biology -- 5 Status Quo -- References -- Clinical Presentation and Prognosis -- 1 Clinical Presentation -- 1.1 General Symptoms -- Epilepsy/Seizures -- Headache and Raised Intracranial Pressure -- Cognitive Function and Psychiatric Manifestations -- 1.2 Focal Symptoms -- Cranial Nerve Deficits -- Cortical Compression Syndromes -- 1.3 Incidental Meningiomas |
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2 Prognosis -- 2.1 Histological Grade -- 2.2 Extent of Resection -- 2.3 Anatomical Location -- Skull Base Tumors -- Venous Sinus Invasion -- 2.4 Molecular Factors and Prognosis -- NF2 -- TRAF7, AKT1, and KLF4 -- Smoothened -- PI3KCA -- POLR2 -- TERT -- FOXM1 -- 2.5 Epigenetic Changes: Methylation-Based Classification -- 3 Conclusions and Future Directions -- References -- Imaging Characteristics of Meningiomas -- 1 Imaging Findings in Meningioma on Anatomical CT and MRI -- 2 Alternative Imaging Methods -- 3 Advanced MRI -- 4 Most Relevant Clinical Applications for Advanced MRI |
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4.1 Differential Diagnosis -- 5 Meningioma Grading -- 6 Meningioma Relapse Risk Stratification -- 7 Molecular PET Imaging -- 8 Selected Tracers for PET Imaging in Meningioma Patients -- 8.1 Glucose PET -- 9 PET Ligands for Somatostatin Receptors -- 10 Amino Acid PET Tracers -- 11 Clinical Applications for PET Imaging -- 11.1 Meningioma Detection and Delineation -- 12 Radiotherapy Planning -- 13 Diagnosis of Meningioma Relapse -- 14 PET-Based Theranostics in Patients with Meningioma -- 15 Conclusions -- References -- Histopathology of Meningiomas -- 1 Introduction |
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2 Gross Pathology -- 3 Intraoperative Cytology -- 4 Histological Variants and Grading -- 4.1 Meningothelial Meningioma -- 4.2 Fibrous/Fibroblastic Meningioma -- 4.3 Transitional Meningioma -- 4.4 Psammomatous Meningioma -- 4.5 Angiomatous/Vascular Meningioma -- 4.6 Microcystic Meningioma -- 4.7 Secretory Meningioma -- 4.8 Lymphoplasmacyte-Rich Meningioma -- 4.9 Metaplastic Meningiomas -- 4.10 WHO Grade 2 and Grade 3 Meningiomas -- 4.11 Atypical Meningioma -- 4.12 Clear Cell Meningiomas -- 4.13 Chordoid Meningioma -- 4.14 Anaplastic/Malignant Meningioma |
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4.15 Papillary Meningioma -- 4.16 Rhabdoid Meningioma -- 4.17 Rare Morphological Variants -- 5 Immunohistochemistry -- 6 Electron Microscopy -- 7 Differential Diagnosis -- References -- Skull Base Meningiomas -- 1 Introduction -- 2 Meningiomas of the Anterior Skull Base -- 2.1 Olfactory Grove Meningiomas -- 2.2 Meningiomas of the Planum Sphenoidale -- 2.3 Tuberculum Sellae Meningiomas -- 2.4 Orbital or Spheno-Orbital Meningiomas -- 3 Meningiomas of the Middle Skull Base -- 3.1 Clinoidal Meningiomas -- 3.2 Medial Sphenoid Wing Meningiomas -- 3.3 Cavernous Sinus Meningiomas |
| Summary |
"Meningiomas are tumors that originate from the arachnoidal cap cells of the leptomeninges. With an incidence rate of 8.36 per 100, 000 population, they are the most common primary central nervous system (CNS) tumors, accounting for a third of all cases. The World Health Organization (WHO) classification has traditionally categorized meningiomas into 15 different histopathological subtypes and three clinical grades. Tumors are classified as WHO grades 1, 2 or 3 based largely on histopathological features such as mitotic activity, presence of brain invasion, and other atypical features. However, there is increasing recognition of the limitations of histopathology including but not limited to: confounding factors such as sampling bias in a heterogeneous tumor, and technical factors related to the experience of the grading pathologist. Even with careful histologic grading, there remains significant variability in recurrence rates within each tumor grade. As more studies have uncovered the molecular features of meningiomas, novel biological alterations have helped refine classification schemes that more accurately reflect patient outcomes. This book reviews the current state of knowledge on the genomic and epigenomic landscape of meningiomas in order to identify the roles of genomic aberrations on diagnosis, prognosis, and treatment of meningiomas in addition to mainstays of surgical management, radiation therapy, and potential novel chemotherapies. Written by a team of world-renowned experts in neurosurgery, neuropathology, radiology, and radiation-oncology, this book is the definitive resource on meningioma management and investigation for both clinicians and scientists alike." |
| Notes |
3.4 Middle Fossa/Temporobasal Meningiomas and Meningiomas of the Lateral and Middle Third of the Lesser Sphenoid Wing |
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Includes index |
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Description based on online resource; title from digital title page (viewed on October 06, 2023) |
| Subject |
Meningioma.
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Meningioma
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Meningioma.
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| Form |
Electronic book
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| Author |
Zadeh, Gelareh, editor.
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Goldbrunner, Roland, editor.
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Krischek, Boris, 1972-2021, editor.
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Nassiri, Farshad, editor.
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| ISBN |
9783031297502 |
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3031297504 |
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