Title The immune synapse as a novel target for therapy / Luis Graca, editor

Published Basel ; Boston : Birkhäuser ; [London] : [Springer, distributor], ©2008

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Description 1 online resource (xi, 192 pages) : illustrations Series Progress in inflammation research PIR (Series) Contents The immune synapse and T cell activation: regulation by chemokines -- The induction of regulatory T cells by targeting the immune synapse -- Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology -- Targeting CD4 for the induction of dominant tolerance -- Anti-CD3: from T cell depletion to tolerance induction -- Immune modulation by CD40L blockade -- CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance -- Adhesion molecules as therapeutic targets -- E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within? -- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells -- Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance -- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic Summary The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell-APC junction. It plays an essential role in the control and nature of the immune response. In recent years several approaches have been developed to reprogramming the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as the ones targeting the lymphocyte co-receptor, co-stimulatory and adhesion molecules (CD3, CD4, CD Bibliography Includes bibliographical references and index Notes Print version record In Springer eBooks Subject Synapses. Immune response -- Molecular aspects. Immune response -- Regulation. Antigen Presentation -- physiology Immunological Synapses -- physiology T-Lymphocytes -- physiology Synapses MEDICAL -- Immunology. Immune response -- Regulation. T-Lymphocytes -- physiology. Lymphocyte Activation. Antigens, CD -- physiology. Antigen Presentation. Immune Tolerance. Synapses. Immune response -- Molecular aspects. Biomédecine. Sciences de la vie. Immune response -- Molecular aspects Immune response -- Regulation Synapses Form Electronic book Author Graca, Luis, MD. LC no. 2007934182 ISBN 9783764382964 3764382961 9783764382957 3764382953 9786611140915 6611140913

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