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Title Childhood acute lymphoblastic leukemia / Ajay Vora, editor
Published Cham, Switzerland : Springer, 2017
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Description 1 online resource (ix, 342 pages) : illustrations (some color)
Contents Contributors; Chapter 1: Epidemiology and Etiology of Childhood ALL; 1.1 Introduction; 1.2 General Epidemiology; 1.3 Natural History; 1.4 Environmental Risk Factors; 1.4.1 Infectious Disease and Immune Stimulation; 1.4.2 Other Risk Factors; 1.5 Heritability of ALL; 1.6 High-Penetrance Genetic Predisposition; 1.6.1 Syndromes Where ALL Is a Dominant Cancer Phenotype; 1.6.2 Syndromes Where ALL Is Part of a Mixed Cancer Phenotype; 1.7 Low-Penetrance Genetic Predisposition; 1.8 Future Directions; References; Chapter 2: Clinical Presentation and Prognostic Factors
2.1 Clinical Presentation2.1.1 Introduction; 2.1.2 Symptoms and Signs Related to Bone Marrow Involvement; 2.1.3 Symptoms and Signs Related to Extensive Bulk Disease; 2.1.4 Central Nervous System; 2.1.5 The Eye; 2.1.6 Genitourinary System; 2.1.7 Cardiovascular System; 2.1.8 The Skin; 2.1.9 Head and Neck; 2.1.10 Gastrointestinal System; 2.1.11 Hypercalcaemia; 2.1.12 Haemophagocytic Lymphohistiocytosis (HLH); 2.1.13 Aplastic Presentation; 2.1.14 Rare Presentations; 2.1.15 Asymptomatic Pancytopenia; 2.1.16 The Diagnostic Interval and Pathway; 2.1.17 Differential Diagnosis; 2.2 Laboratory Features
2.2.1 Haematology2.2.2 Biochemistry; 2.2.3 Bone Marrow Aspirate; 2.2.4 Lumbar Puncture; 2.3 Diagnostic Workup; 2.4 Prognostic Factors; 2.5 Individual Prognostic Factors; 2.5.1 Age; 2.5.2 White Cell Count; 2.5.3 NCI Risk Score; 2.5.4 Gender; 2.5.5 CNS Disease; 2.5.6 Disease Bulk; 2.5.7 Immunophenotype; 2.5.8 Genetics; 2.5.9 Response to Treatment; References; Chapter 3: Diagnostic Flow Cytometry and Immunophenotypic Classification; 3.1 Introduction; 3.2 Immunophenotype of T-Lymphoblastic Leukemia/Lymphoma; 3.3 Early T-Cell Precursor ALL; 3.4 Immunophenotype of B-Lymphoblastic Leukemia/Lymphoma
3.5 Acute Leukaemia of Ambiguous Lineage3.6 Antigen Expression: Correlation to Prognosis and Cytogenetics; 3.7 Extended Leukaemia Immunophenotyping; 3.8 Conclusions and Perspective; References; Chapter 4: Cytogenetics and Molecular Genetics; 4.1 Introduction; 4.2 Abnormality Detection Methodologies; 4.3 Chromosomal Abnormalities in BCP-ALL; 4.3.1 Favourable Risk Abnormalities; 4.3.1.1 High Hyperdiploidy; 4.3.1.2 t(12; 21)(p13; q22)/ETV6-RUNX1; 4.3.1.3 t(1; 19)(q23; p13)/TCF3-PBX1; 4.3.2 Poor-Risk Chromosomal Abnormalities; 4.3.2.1 t(9; 22)(q34; q11.1)/BCR-ABL1; 4.3.2.2 t(17; 19)(q22
P13)/TCF3-HLF4.3.2.3 11q23/KMT2A Gene Rearrangements; 4.3.2.4 Near-Haploidy and Low Hypodiploidy; 4.3.2.5 Intrachromosomal Amplification of Chromosome 21 (iAMP21); 4.3.3 B-ALL Lacking Sentinel Chromosomal Rearrangements; 4.3.3.1 Ph-Like or BCR-ABL1-Like ALL; 4.3.3.2 CRLF2 Rearrangements and Janus Kinase Mutations in ALL; 4.3.3.3 DUX4 and ERG-Deregulated ALL; 4.3.3.4 Translocations Involving the IGH Locus; 4.3.3.5 PAX5 Rearrangements; MEF2D and ZNF384 Gene Fusions; ETV6-RUNX1-Like; 4.3.4 Secondary Genetic Alterations in BCP-ALL; 4.4 Genetic Rearrangements in T-Lineage ALL
Summary This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia
Notes Includes index
Online resource; title from PDF title page (SpringerLink, viewed April 27, 2017)
Subject Lymphoblastic leukemia in children -- Diagnosis.
Lymphoblastic leukemia in children -- Treatment.
Lymphoblastic leukemia in children.
Form Electronic book
Author Vora, Ajay, editor
ISBN 3319397087 (electronic bk.)
9783319397085 (electronic bk.)
(print)