| Description |
1 online resource (xxi, 467 pages) : illustrations |
| Contents |
New Insights into the Extracellular Matrix. -- Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors. -- Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates. -- Functions of Proteoglycan/Glycosaminoglycan in Liver; SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology. -- Cells Responsible for ECM Production in the Liver. Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential. -- Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair. -- Molecular Mechanism of Stellate Cell Activation and ECM Remodeling. -- Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype. Knockout Mice of Matrix Metalloproteinase Genes. Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis |
| Summary |
Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology |
| Analysis |
matrixeiwitten |
|
matrix proteins |
|
metalloproteins |
|
metalloproteinases |
|
remmers |
|
inhibitors |
|
gentherapie |
|
gene therapy |
|
behandeling |
|
treatment |
|
cirrose |
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cirrhosis |
|
leverziekten |
|
liver diseases |
|
lever |
|
liver |
|
Human Pathology |
|
Humane pathologie |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Liver -- Cirrhosis -- Treatment
|
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Liver -- Cirrhosis -- Gene therapy
|
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Extracellular matrix.
|
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Liver Cirrhosis -- pathology
|
|
Extracellular Matrix
|
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Extracellular Matrix -- genetics
|
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Liver Cirrhosis -- therapy
|
|
Extracellular matrix
|
|
Liver -- Cirrhosis -- Treatment
|
| Genre/Form |
proceedings (reports)
|
|
Conference papers and proceedings
|
|
Conference papers and proceedings.
|
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Actes de congrès.
|
| Form |
Electronic book
|
| Author |
Okazaki, Isao
|
| ISBN |
9780125252515 |
|
012525251X |
|
1281037729 |
|
9781281037725 |
|
9786611037727 |
|
6611037721 |
|
0080531504 |
|
9780080531502 |
|
