| Description |
1 online resource : colour illustrations |
| Contents |
880-01 Cover; Title Page; Copyright Page; Dedication; Contents; List of Contributors; Editor Biography; Foreword; Liver stem cells: are they real or illusions?; Preface; Acknowledgments; Introduction; References; Chapter 1 -- Molecular Mechanisms of Liver Development: Lessons From Animal Models; 1 -- Introduction; 2 -- Liver development; 2.1 -- Chronology of Liver Bud Formation; 2.2 -- Genes Involved in Liver Bud Formation; 2.3 -- Hepatocyte and Cholangiocyte Differentiation; 2.4 -- Mesothelial Cell Differentiation; 2.5 -- Hepatic Stellate Cell Differentiation; 2.6 -- LSEC Differentiation |
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880-01/(S 4.1 -- Lineage Plasticity of Hepatocytes4.2 -- Heterogeneity of Hepatocytes; 4.3 -- Molecular Mechanisms Regulating Lineage Plasticity of Hepatocytes; 4.3.1 -- Notch Pathway; 4.3.2 -- Hippo Pathway; 4.3.3 -- FGF Signal; 4.3.4 -- TGFβ Signal; 4.3.5 -- Wnt-β-Catenin Pathway; 5 -- Concluding remarks; Abbreviations; References; Chapter 4 -- Stem Cells in the Liver Cancer and the Organ Size Control; 1 -- Introduction; 2 -- Stem cells in the liver; 3 -- Liver cancer and cancer stem Cells; 4 -- Liver organ size; 5 -- Epigenetic deregulation in HCC; 5.1 -- DNA Methylation |
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2.7 -- Differentiation of Kupffer Cells and Pit Cells3 -- Studies of liver formation using zebrafish; 4 -- Studies of liver formation using medaka; 4.1 -- Group 1: Mutations Affecting Hepatoblast Development; 4.2 -- Group 2: Mutations Affecting Hepatoblast Proliferation; 4.3 -- Group 3: Mutations Affecting Liver Laterality; 4.4 -- Group 4: Mutations Affecting Hemoglobin-Bilirubin Metabolism; 4.5 -- Group 5: Mutations Affecting Lipid Metabolism; 4.6 -- Analysis of Medaka Mutants; 5 -- Studies of liver size regulation in mice; 6 -- Human liver diseases; 6.1 -- Hepatocellular Carcinoma |
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6.2 -- Metabolic Disorders6.3 -- Alagille Syndrome; 7 -- Conclusion; List of acronyms and abbreviations; References; Chapter 2 -- Molecular Mechanisms Regulating the Proliferation and Maturation of Hepatic Progenitor Cells During Liver Devel ... ; 1 -- Introduction; 2 -- Liver regeneration and normal liver-derived stem/progenitor cells; 3 -- Regulation of transcription factors regulating the proliferation and maturation of hepatic progenitor cells; 4 -- Signaling pathways regulating hepatoblast proliferation and differentiation; 5 -- Hepatic progenitor cells derived from human pluripotent stem cells |
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6 -- ConclusionFinancial support and sponsorship; Acknowledgments; List of abbreviations; References; Chapter 3 -- Plasticity of Liver Epithelial Cells in Healthy and Injured Livers; 1 -- Introduction; 2 -- Lineage specification during development; 3 -- Lineage plasticity and heterogeneity of cholangiocytes; 3.1 -- Lineage Plasticity of Cholangiocytes; 3.1.1 -- Fetal and Neonatal Cholangiocytes; 3.1.2 -- Adult Cholangiocytes; 3.2 -- Heterogeneity of Cholangiocytes; 3.3 -- Molecular Mechanisms Regulating the Plasticity of Cholangiocytes; 4 -- Lineage plasticity and heterogeneity of hepatocytes |
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5.2 -- Histone Modification and Chromatin Structure |
| Summary |
Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed May 25, 2018) |
| Subject |
Hepatology.
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Stem cells.
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Liver -- Diseases.
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Liver -- Cancer.
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Liver -- cytology
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Stem Cells -- physiology
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Stem Cells -- pathology
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Liver Neoplasms -- physiopathology
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Cell Transplantation
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Gastroenterology
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Stem Cells
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Liver Neoplasms
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Hepatology
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Liver -- Cancer
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Liver -- Diseases
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Stem cells
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| Form |
Electronic book
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| Author |
Zheng, Yun-Wen, editor
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| ISBN |
9780128123027 |
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0128123028 |
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