| Description |
1 online resource |
| Contents |
Title Page -- Copyright Page -- Contents -- List of Contributors -- Chapter 1 Hepatocytes -- Introduction -- Liver and hepatocyte development -- Phenotype and regeneration of the mature hepatocyte -- Metabolic functions of the liver -- Resorption, storage, and synthesis -- Detoxification and excretion -- Detoxification of specific substances -- Excretion -- Multiple choice questions -- References -- Chapter 2 Signaling pathways in biliary epithelial cells -- Introduction -- Membrane receptors -- Cyclic adenosine 3�, 5�-monophosphate (cAMP) |
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Cytosolic Ca2+Protein kinase C -- Mitogen-activated protein kinase signaling -- Phosphotidylinositol 3-kinase signaling -- Notch signaling -- Hedgehog signaling -- Vascular endothelial growth factor -- Pathological conditions -- Conclusion -- Acknowledgments -- Multiple choice questions -- References -- Chapter 3 Stellate cells -- Polypeptide growth factor receptors -- Transforming growth factor-β receptor superfamily -- Seven transmembrane domain receptors -- Chemokines -- Tumor necrosis factor receptor superfamily -- Nuclear receptor family |
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Other cytokine receptorsAdipokine receptors -- Extracellular matrix signaling and hepatic stellate cells -- Toll-like receptors -- Cannabinoid receptors -- Hedgehog pathway -- Wnt pathway -- Autophagy -- Senescence of activated stellate cells -- miRNAs and hepatic stellate cells -- Conclusion -- Multiple choice questions -- References -- Chapter 4 Kupffer cells -- Introduction -- Markers, origin, and heterogeneity of Kupffer cells -- M1 versus M2 polarization in Kupffer cells -- Lipopolysaccharide signaling and endotoxin tolerance |
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Experimental approaches to deplete Kupffer cells in vivoRole of Kupffer cells in liver disease -- Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis -- Alcoholic liver disease -- Liver regeneration -- Liver fibrosis and cirrhosis -- Ischemia-reperfusion liver injury -- Primary and metastatic liver tumors -- Infectious diseases -- Clinical applications and future perspectives -- Acknowledgment -- Multiple choice questions -- References -- Chapter 5 Hepatic sinusoidal endothelial cells -- Development and structure -- Cellular functions |
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Filtration via fenestraeDiapedesis -- Nitric oxide signaling -- Endocytosis -- Bacterial processing -- Liver regeneration -- Pathobiology -- Fibrosis and cirrhosis -- Alcoholic liver disease -- Nonalcoholic fatty liver disease -- Hepatic malignancies -- Drug toxicity -- Ischemia-reperfusion injury -- Aging process -- Conclusion -- Multiple choice questions -- References -- Chapter 6 Extracellular matrix -- Introduction -- Components of the extracellular matrix in liver (Figure 6.1) -- The collagen scaffold -- Proteoglycans -- Laminin |
| Summary |
Signalling Pathways in Liver Diseases 3E again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signalling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohatitis, cirrhosis and liver tumours, which has led in changes to the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: -Autophagy -Notch Pathway -PI3K/PTEN Signaling in Liver Diseases -Sirtuins -Hepcidin and Iron -Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis -Oxidative Stress and Signaling in the Liver. Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom write a clear yet comprehensive review of their chosen topic. Chapters will contain clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signalling Pathways in Liver Diseases 3E is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist |
| Notes |
Title from resource description page (Recorded Books, viewed October 05, 2015) |
| Subject |
Liver -- Diseases -- Pathophysiology
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Liver -- Cytology
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Cellular signal transduction.
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Signal Transduction
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MEDICAL -- Gastroenterology.
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Cellular signal transduction
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Liver -- Cytology
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| Form |
Electronic book
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| Author |
Clavien, Pierre-Alain
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| ISBN |
9781118663356 |
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1118663357 |
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