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Book Cover
Author Duffy, Colm

Title Heteroaromatic lipoxin A₄ analogues : synthesis and biological evaluation / Colm Duffy
Published Heidelberg ; New York : Springer-Verlag Berlin Heidelberg, ©2012


Description 1 online resource (xxi, 127 pages) : illustrations
Series Springer theses
Springer theses.
Contents Introduction -- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues -- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues -- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues -- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines -- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues
Summary In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation
Analysis Chemistry
Bioorganic chemistry
Biochemistry, general
Medicinal Chemistry
Notes "Doctoral thesis accepted by University College Dublin, Ireland."
Bibliography Includes bibliographical references
Subject Lipoxins -- Synthesis
SCIENCE -- Life Sciences -- Biochemistry.
Science des matériaux.
Form Electronic book
ISBN 9783642246326