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Author Duffy, Colm

Title Heteroaromatic lipoxin A₄ analogues : synthesis and biological evaluation / Colm Duffy
Published Heidelberg ; New York : Springer-Verlag Berlin Heidelberg, ©2012

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Description 1 online resource (xxi, 127 pages) : illustrations
Series Springer theses
Springer theses.
Contents Introduction -- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues -- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues -- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues -- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines -- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues
Summary In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation
Analysis Chemistry
Bioorganic chemistry
Biochemistry
Catalysis
Biochemistry, general
Medicinal Chemistry
Notes "Doctoral thesis accepted by University College Dublin, Ireland."
Bibliography Includes bibliographical references
In Springer eBooks
Subject Lipoxins -- Synthesis
Chemistry.
Pharmaceutical chemistry.
Catalysis.
Biochemistry.
Chemistry
Chemistry, Pharmaceutical
Catalysis
Biochemistry
chemistry.
biochemistry.
SCIENCE -- Life Sciences -- Biochemistry.
Science des matériaux.
Chimie.
Biochemistry
Bioorganic chemistry
Catalysis
Chemistry
Pharmaceutical chemistry
Form Electronic book
ISBN 9783642246326
364224632X
3642246311
9783642246319