| Description |
1 online resource (xxi, 127 pages) : illustrations |
| Series |
Springer theses |
|
Springer theses.
|
| Contents |
Introduction -- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues -- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues -- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues -- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines -- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues |
| Summary |
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation |
| Analysis |
Chemistry |
|
Bioorganic chemistry |
|
Biochemistry |
|
Catalysis |
|
Biochemistry, general |
|
Medicinal Chemistry |
| Notes |
"Doctoral thesis accepted by University College Dublin, Ireland." |
| Bibliography |
Includes bibliographical references |
| Subject |
Lipoxins -- Synthesis
|
|
SCIENCE -- Life Sciences -- Biochemistry.
|
|
Science des matériaux.
|
|
Chimie.
|
| Form |
Electronic book
|
| ISBN |
9783642246326 |
|
364224632X |
|
3642246311 |
|
9783642246319 |
|
