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Uniform Title High density lipoproteins (Eckardstein and Kardasis)
Title High density lipoproteins : from biological understanding to clinical exploitation / Arnold von Eckardstein, Dimitris Kardassis, editors
Published Cham : Springer, [2015]
Online access available from:
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Description 1 online resource (xiii, 694 pages) : illustrations (some color)
Series Handbook of Experimental Pharmacology, 1865-0325 ; volume 224
Handbook of experimental pharmacology ; v. 224. 0171-2004
Contents Part 1: Physiology of HDL. Structure of HDL: particle subclasses and molecular components HDL biogenesis, remodeling, and catabolism -- Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational -- Cholesterol efflux and reverse cholesterol transport -- Functionality of HDL: antioxidation and detoxifying effects -- Signal transduction by HDL: agonists, receptors, and signaling cascades -- Part 2: Pathology of HDL. Epidemiology: disease associations and modulators of HDL-related biomarkers -- Beyond the genetics of HDL: why is HDL cholesterol inversely related to cardiovascular disease? -- Mouse models of disturbed HDL metabolism -- Dysfunctional HDL: from structure-function-relationships to biomarkers -- Part 3: Possible indications and target mechanisms of HDL therapy. HDL and atherothrombotic vascular disease -- HDLs, diabetes, and metabolic syndrome -- High-density lipoprotein: structural and functional changes under uremic conditions and the therapeutic consequences -- Impact of systemic inflammation and autoimmune diseases on apoA-I and HDL plasma levels and functions -- HDL in infectious diseases and sepsis -- High-density lipoproteins in stroke -- Therapeutic potential of HDL in cardioprotection and tissue repair -- Part 4: Treatments for dyslipidemias and dysfunction of HDL. HDL and lifestyle interventions -- Effects of established hypolipidemic drugs on HDL concentration, subclass distribution, and function -- Emerging small molecule drugs -- ApoA-I mimetics -- Antisense oligonucleotides, microRNAs, and antibodies
Summary "In this Handbook of Experimental Pharmacology on "High Density Lipoproteins: from biological understanding to clinical exploitation" contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation"--Publisher's description
Bibliography Includes bibliographical references and index
Notes Online resource; title from resource home page (SpringerLink, viewed April 19, 2016)
Subject High density lipoproteins -- Pathophysiology.
High density lipoproteins -- Physiological effect.
High density lipoproteins -- Therapeutic use.
Lipoproteins, HDL -- physiology.
Lipoproteins, HDL -- physiopathology
Lipoproteins, HDL -- therapeutic use.
Form Electronic book
Author Eckardstein, Arnold von, editor
Kardassis, Dimitris, editor
ISBN 3319096656 (electronic bk.)
9783319096650 (electronic bk.)
(hbk. ;) (alk. paper)
(hbk. ;) (alk. paper)