| Description |
1 online resource (258 pages) : illustrations, tables |
| Contents |
Contributors; Current Books of Interest; Preface; 1: Modulation of Host Cell miRNA Expression During Leishmania Infection and Emergence of miRNA as a New Therapeutic Molecule; miRNA-mediated gene regulation in metazoan animals; miRNA as regulator of cholesterol metabolism in mammals; Cholesterol regulates pathogenesis of Leishmania donovani; Leishmania-mediated changes in cholesterol production in mammals; miRNA expression affected by parasite; Mechanism of miRNA alteration by Leishmania; Factors important for host cell miRNA alteration during infection; miRNA as therapeutic agent |
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Future of miRNA as a therapeutic agent against visceral leishmaniasis2: Heat Shock Proteins of Leishmania: Chaperones in the Driver's Seat; Introduction: heat shock proteins; Heat shock proteins in Leishmania spp.; Leishmania and the cell stress; The pitfalls of analogy-based assumptions; The chaperone machinery and signal transduction in Leishmania; Open questions; Future trends; Acknowledgements; 3: Role of Iron in Leishmania-Macrophage Interaction; Introduction; Aqueous chemistry and toxicity of iron; Role of iron in physiology; Role of iron in the host-parasite interaction |
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Special need of iron for LeishmaniaMammalian iron homeostasis components important for sequestering iron; Regulation of cellular iron metabolism of mammalian host; Source of host iron and its acquisition systems in Leishmania; Summary and future aspects; 4: Oxidative and Nitrosative Stress Response in Leishmania; Introduction; Sources of superoxide and hydrogen peroxide in Leishmania; Targets of reactive oxygen species in Leishmania; Defence against reactive oxygen species; Nitrosative stress in Leishmania; Generation of reactive nitrogen species |
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Targets of reactive nitrogen species (RNS) in LeishmaniaCellular defences against nitrosative stress in Leishmania; Conclusion; Future perspectives; 5: Cell Death in a Kinetoplastid Parasite, the Leishmania spp.; Introduction; Life cycle of Leishmania spp.; Treatment of leishmaniasis; Programmed cell death (PCD); Programmed cell death in protozoan parasites; Relevance of studying cell death in Leishmania; Apoptosis in Leishmania; Natural cell death during cell cycle; Induction of cell death by anti-leishmanial drugs; Oxidative stress induced cell death |
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Role of apoptotic mimicry and apoptosis in LeishmaniaAutophagy in Leishmania; Future trends; Conclusion; 6: Elucidating the Strategies of Immune Evasion by Leishmania; Introduction; Defying recognition by the host: modulation of Toll-like receptor-mediated signalling; Deactivation of host signalling: mitogen-activated protein (MAP) kinases and phosphatases; Disarming the enemy: inhibition of host microbicidal molecules; Delaying phagosome maturation: buying time for promastigote to amastigote conversion; Creating a favourable environment: polarization of Th (T-helper cell) response |
| Summary |
In this timely book respected Leismania experts distil the important current research highlighting the most insightful discoveries in the field. Topics covered include: modulation of host miRNA; heat shock proteins; Iron in the Leishmania-macrophage interaction; oxidative and nitrosative stress response; cell death; strategies for immune evasion; STAT signalling; parasite modulation of toll-like receptors in macrophages; T cells in Leishmania infection; vaccine biology; inhibitors of Leishmania DNA topoisomerases; and mechanism of drug resistance in visceral Leishmaniasis. An essential text fo |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Online resource; title from PDF title page (ebrary, viewed November 11, 2014) |
| Subject |
Leishmania.
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Leishmaniasis -- prevention & control
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Leishmania
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Leishmania
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| Form |
Electronic book
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| Author |
Adak, Subrata, editor, contributor
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Datta, Rupak, editor
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| ISBN |
9781908230539 |
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1908230533 |
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