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Title Molecular mechanisms in Legionella pathogenesis / edited by Hubert Hilbi
Published Heidelberg : Springer, 2014

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Description 1 online resource (x, 295 pages)
Series Current Topics in Microbiology and Immunology, 0070-217X ; volume 376
Current topics in microbiology and immunology ; v. 376. 0070-217X
Contents From Amoeba to Macrophages: Exploring the Molecular Mechanisms of Legionella pneumophila Infection in Both Hosts / Pedro Escoll and Monica Rolando -- The Legionella pneumophila Two-Component Regulatory Systems that Participate in the Regulation of Icm/Dot Effectors / Gil Segal -- Facets of Small RNA-Mediated Regulation in Legionella pneumophila / Hana Trigui, Nilmini Mendis and Laam Li -- Type II Secretion and Legionella Virulence / Nicholas P. Cianciotto -- Effector Translocation by the Legionella Dot/Icm Type IV Secretion System / Jiazhang Qiu and Zhao-Qing Luo -- Modulation of Small GTPases by Legionella / Roger S. Goody and Aymelt Itzen -- Host Lipidation: A Mechanism for Spatial Regulation of Legionella Effectors / Stanimir S. Ivanov and Craig Roy -- Phosphoinositide Lipids and the Legionella Pathogen Vacuole / Ina Haneburger and Hubert Hilbi -- Legionella Phospholipases Implicated in Virulence / Katja Kuhle and Antje Flieger -- Cytotoxic Glucosyltransferases of Legionella pneumophila / Yury Belyi, Thomas Jank and Klaus Aktories -- Modulation of the Ubiquitination Machinery by Legionella / Andree Hubber, Tomoko Kubori and Hiroki Nagai -- Host Signal Transduction and Protein Kinases Implicated in Legionella Infection / Andrew D. Hempstead and Ralph R. Isberg -- Mouse Models of Legionnaires' Disease / Andrew S. Brown and Ian R. van Driel
Summary Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila
Analysis geneeskunde
medicine
biomedische wetenschappen
biomedicine
immunologie
immunology
bacteriologie
bacteriology
microbiologie
microbiology
infectieziekten
infectious diseases
Medicine (General)
Geneeskunde (algemeen)
Notes Includes index
Online resource; title from PDF title page (SpringerLink, viewed October 28, 2013)
Subject Legionella pneumophila.
Legionnaires' disease -- Molecular aspects
Legionnaires' disease.
Pathology, Molecular.
Legionella pneumophila
Legionnaires' Disease
Pathology, Molecular
Legionellosis
Pathology, Molecular
Legionnaires' disease
Legionella pneumophila
Form Electronic book
Author Hilbi, Hubert, editor
ISBN 9783642405914
3642405916