| Description |
1 online resource (x, 295 pages) |
| Series |
Current Topics in Microbiology and Immunology, 0070-217X ; volume 376 |
|
Current topics in microbiology and immunology ; v. 376. 0070-217X
|
| Contents |
From Amoeba to Macrophages: Exploring the Molecular Mechanisms of Legionella pneumophila Infection in Both Hosts / Pedro Escoll and Monica Rolando -- The Legionella pneumophila Two-Component Regulatory Systems that Participate in the Regulation of Icm/Dot Effectors / Gil Segal -- Facets of Small RNA-Mediated Regulation in Legionella pneumophila / Hana Trigui, Nilmini Mendis and Laam Li -- Type II Secretion and Legionella Virulence / Nicholas P. Cianciotto -- Effector Translocation by the Legionella Dot/Icm Type IV Secretion System / Jiazhang Qiu and Zhao-Qing Luo -- Modulation of Small GTPases by Legionella / Roger S. Goody and Aymelt Itzen -- Host Lipidation: A Mechanism for Spatial Regulation of Legionella Effectors / Stanimir S. Ivanov and Craig Roy -- Phosphoinositide Lipids and the Legionella Pathogen Vacuole / Ina Haneburger and Hubert Hilbi -- Legionella Phospholipases Implicated in Virulence / Katja Kuhle and Antje Flieger -- Cytotoxic Glucosyltransferases of Legionella pneumophila / Yury Belyi, Thomas Jank and Klaus Aktories -- Modulation of the Ubiquitination Machinery by Legionella / Andree Hubber, Tomoko Kubori and Hiroki Nagai -- Host Signal Transduction and Protein Kinases Implicated in Legionella Infection / Andrew D. Hempstead and Ralph R. Isberg -- Mouse Models of Legionnaires' Disease / Andrew S. Brown and Ian R. van Driel |
| Summary |
Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila |
| Analysis |
geneeskunde |
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medicine |
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biomedische wetenschappen |
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biomedicine |
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immunologie |
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immunology |
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bacteriologie |
|
bacteriology |
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microbiologie |
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microbiology |
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infectieziekten |
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infectious diseases |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Notes |
Includes index |
|
Online resource; title from PDF title page (SpringerLink, viewed October 28, 2013) |
| Subject |
Legionella pneumophila.
|
|
Legionnaires' disease -- Molecular aspects
|
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Legionnaires' disease.
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Pathology, Molecular.
|
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Legionella pneumophila
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Legionnaires' Disease
|
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Pathology, Molecular
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Legionellosis
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Pathology, Molecular
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Legionnaires' disease
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Legionella pneumophila
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| Form |
Electronic book
|
| Author |
Hilbi, Hubert, editor
|
| ISBN |
9783642405914 |
|
3642405916 |
|
