| Description |
1 online resource (1162 pages) |
| Contents |
Cover; Half Title; Title Page; Copyright Page; Dedication Page; Contents; List of Contributors; List of Reviewers; Chapter 1: The Laboratory Mouse; 1.1 Introduction; 1.2 Unique Physiological Characteristics of the Laboratory Mouse; 1.3 Methodology for Sample Collection; 1.3.1 Blood Collection; 1.3.1.1 Collection Volume Limits and Frequency of Collection; 1.3.1.2 Primary Sites for Collection and Restraint; 1.3.1.3 Handling and Storage; 1.3.1.4 Serum; 1.3.1.5 Plasma; 1.3.1.6 Choice of Anticoagulant; 1.3.1.7 Storage; 1.3.2 Urine Collection and Storage; 1.4 Preanalytical Sources of Variation |
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1.4.1 Sex1.4.2 Age; 1.4.3 Genetics; 1.4.4 Health Status; 1.4.5 Nutritional Status; 1.4.5.1 Diet; 1.4.5.2 Fasting; 1.4.5.3 Caloric Restriction; 1.4.6 Environment; 1.4.7 Circadian Rhythm; 1.4.8 Pregnancy; 1.4.9 Stress; 1.4.10 Anesthesia; 1.4.11 Specimen Collection and Handling; 1.4.11.1 Interfering Constituents; 1.4.11.2 Site of Sampling; 1.5 Basic Methodology for Common Procedures; 1.5.1 Adrenocorticotropin Hormone Stimulation Test; 1.5.2 Water Deprivation; 1.5.3 Ammonia Tolerance Test; 1.5.4 Indocyanine Green Elimination Test; 1.5.5 Bile Acidsâ#x80;#x94;Pre- and Postprandial |
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1.5.6 Bromosulphthalein Clearance1.5.7 Low-Dose Dexamethasone Suppression Test; 1.5.8 High-Dose Dexamethasone Suppression Test; 1.5.9 Intraperitoneal Glucose Tolerance Test; 1.5.10 Oral Glucose Tolerance Test; 1.5.11 Inulin Clearanceâ#x80;#x94;Single Bolus Injection Method; 1.5.12 TSH (Thyrotropin) Stimulation Test; 1.5.13 Thyrotropin-Releasing Hormone Stimulation Test; 1.6 Reference Ranges; References; Chapter 2: The Laboratory Rat; 2.1 Introduction; 2.2 History of Laboratory Rats; 2.3 Anatomic and Physiologic Characteristics of Laboratory Rats; 2.4 Genetic Characteristics and Background Lesions |
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2.5 Methodology for Sample Collection2.5.1 Blood Collection (for Serum or Plasma); 2.5.2 Urine Collection; 2.6 Sources of Variation; 2.6.1 Sex and Age; 2.6.2 Genetic Influence; 2.6.3 Nutritional Status; 2.6.4 Caging; 2.6.5 Circadian Rhythm; 2.6.6 Effects of Estrous Cycle, Pregnancy, or Lactation; 2.6.7 Fasting; 2.6.8 Handling; 2.6.9 Restraint; 2.6.10 Anesthesia; 2.6.11 Site of Blood Collection; 2.6.12 Volume of Blood Collected; 2.6.13 Post-Collection Processing Artifacts; 2.7 Reference Intervals for Laboratory Rats; References; Chapter 3: The Laboratory Rabbit |
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3.1 Use of Rabbits in Biomedical Research3.1.1 Examples of Existing Rabbit Models; 3.1.2 Mutant and Genetically Modified Strains; 3.2 Unique Physiological Characteristics of Rabbit; 3.3 Methodology for Sample Collection; 3.3.1 Blood Collection; 3.3.1.1 Primary Sites for Collection; 3.3.1.2 Methods of Restraint; 3.3.1.3 Collection Volume and Frequency; 3.3.2 Urine Collection; 3.4 Preanalytical Sources of Variation; 3.4.1 Sex; 3.4.2 Age; 3.4.3 Strain/Breed; 3.4.3.1 WHHL Rabbits; 3.4.4 Nutritional Status; 3.4.4.1 Diet Composition; 3.4.4.2 Acute Fasting; 3.4.4.3 Long-Term Dietary Restriction |
| Notes |
3.4.5 Housing Environment |
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Print version record |
| Subject |
Laboratory animals -- Metabolism
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| Form |
Electronic book
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| Author |
Travlos, Gregory S
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| ISBN |
9781351643092 |
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1351643096 |
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