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Title Kallmann syndrome and hypogonadotropic hypogonadism / volume editor, Richard Quinton
Published Basel [Switzerland] ; New York : Karger, ©2010


Description 1 online resource (x, 174 pages) : illustrations (some color)
Series Frontiers of hormone research, 0301-3073 ; v. 39
Frontiers of hormone research ; v. 39.
Contents Molecular characterization and phenotypic expression of mutations in genes for gonadotropins and their receptors in humans / Salvi, R., Pralong, F.P -- Role of kisspeptin/GPR54 system in human reproductive axis / Silveira, L.F.G. [and others] -- Biology of kisspeptins / Hameed, S., Dhillo, W.S. -- Role of fibroblast growth factor signaling in gonadotropin-releasing hormone neuronal system development / Chung, W.C.J., Tsai, P.-S. -- FGFR1 mutations in Kallmann syndrome / Villanueva, C., de Roux, N. -- Biology of KAL1 and its orthologs : implications for x-linked Kallmann syndrome and the search for novel candidate genes / MacColl, G.S., Quinton, R., Bülow, H.E. -- Biological actions and interactions of anosmin-1 / Choy, C., Kim, S.H. -- Genotype and phenotype of patients with gonadotropin-releasing hormone receptor mutations / Kim, H.-G. [and others] -- Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans / Bouligand, J. [and others] -- Kallmann syndrome caused by mutations in the PROK2 and PROKR2 genes : pathophysiology and genotype-phenotype correlations / Sarfati, J., Dodé, C., Young, J. -- Neurokinin B and its receptor in hypogonadotropic hypogonadism / Semple, R.K., Topaloglu, A.K. -- Complex genetics in idiopathic hypogonadotropic hypogonadism / Pitteloud, N. [and others] -- Rarer syndromes characterized by hypogonadotropic hypogonadism / Aminzadeh, M. [and others]
Summary Over the past decade, the understanding of the processes involved in the regulation of gonadotropin-releasing hormone and its dysfunction has greatly increased. As new regulatory peptides have been identified, the underlying causes of central hypogonadism have multiplied, and the area has become increasingly complex. The reversibility of even genetically determined hypogonadotropic hypogonadism has become more firmly established, and clinical studies have greatly expanded our understanding of basic physiological pathways. Structuring this mass of new knowledge in thirteen comprehensive chapters, a group of renowned experts, representing the principal international research groups, take stock of the most recent progress. This up-to-date overview helps scientists and clinicians to plan future research and treat patients with delayed puberty, hypogonadotropic hypogonadism and other forms of central reproductive disorders
Bibliography Includes bibliographical references and indexes
Subject Hypogonadism.
Hypogonadism -- genetics
Kallmann Syndrome -- genetics
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Form Electronic book
Author Quinton, Richard
ISBN 9783805586184