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Author Crichton, Robert R.

Title Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical consequences / Robert Crichton ; with the collaboration of Johan Boelart [and others]
Edition Second edition
Published Chichester, West Sussex ; New York : Wiley, [2001]
Online access available from:
Wiley Online Books    View Resource Record  


Description 1 online resource (xxii, 326 pages, 16 pages of plates) : illustrations (some color
Series Wiley InterScience electronic collection
Contents 4.5 Iron Transport in Other Fungi -- 4.6 References -- 5 Cellular Iron Uptake in Mammals -- 5.1 The Transferrins -- 5.2 Iron Uptake by Mammalian Cells -- Uptake of Transferrin-bound Iron -- 5.3 Iron Uptake by Mammalian Cells -- Uptake of Non-transferrin Bound Iron -- 5.4 References -- 6 Intracellular Iron Storage and Biomineralization -- 6.1 Intracellular Iron Storage -- 6.2 Biomineralization -- 6.3 References -- 7 Intracellular Iron Metabolism and Cellular Iron Homeostasis -- 7.1 Intracellular Iron Metabolism -- 7.2 Metal Ion Homeostasis -- 7.3 References -- 8 Iron Absorption in Mammals with Particular Reference to Man -- 8.1 Iron Metabolism in Man: An Overview -- 8.2 Sources of Dietary Iron in Man and the Importance of Luminal Factors -- 8.3 Molecular Mechanisms of Mucosal Iron Absorption -- 8.4 A Model of Iron Uptake and Regulation of Iron Homeostasis by the Enterocyte -- 8.5 References -- 9 Pathophysiology of Iron Deficiency and Iron Overload in Man
9.1 Introduction: Acquired and Genetic Disorders of Iron Metabolism -- 9.2 Body Iron Regulation -- 9.3 Iron Absorption in Disorders of Iron Metabolism -- 9.4 Iron Deficiency -- 9.5 Iron Overload -- 9.6 Conclusion -- 9.7 References -- 10 Iron and Oxidative Stress -- 10.1 Introduction -- 10.2 Iron and Fenton Chemistry -- 10.3 Importance of Cytoprotection -- 10.4 Importance of Cell Type in Response to Oxidative Stress -- 10.5 Natural Resistance-associated Macrophage Protein (Nramp1) -- 10.6 Ageing of Cells -- 10.7 Cell Signalling and Iron -- 10.8 Apoptosis -- 10.9 Relationship Between NFKB and NO -- 10.10 How Does NO and H2O2 Affect the Iron Regulatory Proteins IRP-1 and IRP-2 -- 10.11 Diseases in which Increases in Iron may be Associated with Increased Oxidative Stress in the Cell -- 10.12 Diseases in which Iron Plays an Important Role -- 10.13 Neurodegenerative Diseases --tidtid62
Cover -- Contents -- Preface -- 1 Solution Chemistry of Iron in Biological Media -- 1.1 Aqueous Solution Chemistry of Iron -- 1.2 Oxygen Free Radicals -- 1.3 Iron Hydrolysis -- A Ubiquitous Phenomenon -- 1.4 Hydrolysis of Iron(III) in Acid Media -- Formation of Polynuclear Species -- 1.5 Formation of Precipitates -- 1.6 Biomineralization -- 1.7 References -- 2 The Importance of Iron for Biological Systems -- 2.1 Introduction -- 2.2 Physical Techniques for the Study of Iron in Biological Systems -- 2.3 Haemoproteins -- 2.4 Iron-Sulfur Proteins -- 2.5 Other Iron-containing Proteins -- 2.6 References -- 3 Microbial Iron Uptake -- 3.1 Introduction -- 3.2 Siderophores -- 3.3 Ferrous Iron Transport Systems -- 3.4 Iron Metabolism -- 3.5 Iron Regulation in Bacteria -- the Fur Protein -- 3.6 Acknowledgements -- 3.7 References -- 4 Iron Uptake by Plants and Yeast -- 4.1 Iron Acquisition by Plants -- 4.2 Plant Ferritins -- 4.3 Iron Acquisition by Yeast -- 4.4 Intracellular Iron Metabolism
Summary Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well-established role in infections by a wide range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. The first edition of this book was published in 1991. Since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of iron homeostasis. The application of molecular biological techniques to cellular biology of iron metabolism has resulted in a rapid expansion in the literature and has precipitated the need for this second edition. Unlike the first edition this book is a collaboration between five authors providing expert knowledge in their individual specialist areas of research. Written, like the first edition, in a relaxed and humorous style, this new edition has many additional features including: * use of illustrations - including extensive use of colour - to make basic concepts clearer * a new chapter dealing with the interactions of iron with other metals particularly copper and zinc * an extensive and up-to-date bibliography. Inorganic Biochemistry of Iron Metabolism, Second Edition is both authoritative - author collaboration ensures coverage by specialists in a coherent manner and comprehensive - both fundamental concepts and applied aspects are covered. It will be essential reading for many researchers in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. These will include bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism and pharmacologists in the pharmaceutical industry interested in developing novel iron binding drugs.rgy
Analysis Biochemistry
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Iron proteins.
Iron -- Metabolism -- Disorders.
Iron -- Metabolism.
Iron Metabolism Disorders.
Iron -- metabolism.
Metabolic Diseases -- physiopathology.
Metalloproteins -- metabolism.
Form Electronic book
Author Boelaert, Johan R.
ISBN 0470845791 (electronic bk.)
0470852038 (electronic bk.)
9780470845790 (electronic bk.)
9780470852033 (electronic bk.)
(alk. paper)
(alk. paper)