Title Analgesia : methods and protocols / edited by Arpad Szallasi

Published New York : Humana Press, ©2010

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Description 1 online resource (xvii, 560 pages) : illustrations Series Springer protocols Methods in molecular biology, 1064-3745 ; 617 Springer protocols (Series) Methods in molecular biology (Clifton, N.J.) ; v. 617. 1064-3745 Contents Alternatives to mammalian pain models 1 : use of C. elegans for the study of volatile anesthetics / Louise M. Steele, Margaret M. Sedensky, and Phil G. Morgan -- Alternatives to mammalian pain models 2 : using Drosophila to identify novel genes involved in nociception / Jason C. Caldwell and W. Daniel Tracey Jr. -- Animal models of acute surgical pain / Hyanin Kim, Backil Sung, and Jianren Mao -- Animal models of acute and chronic inflammatory and nociceptive pain / Janel M. Boyce-Rustay, Prisca Honore, and Michael F. Jarvis -- Noxious heat threshold measured with slowly increasing temperatures : novel rat thermal hyperalgesia models / Kata Bölcskei, Gábor Pethő, and János Szolcsányi -- Locomotor activity in a novel environment as a test of inflammatory pain in rats / David J. Matson, Daniel C. Broom, and Daniel N. Cortright -- Rationale and methods for assessment of pain-depressed behavior in preclinical assays of pain and analgesia / S. Stevens Negus [and others] -- Animal models of orofacial pain / Asma Khan and Kenneth M. Hargreaves -- Migraine models / Silvia Benemei [and others] -- Experimental models of visceral pain / Mia Karpitschka and Martin E. Kreis -- Human correlates of animal models of chronic pain / Arpad Szallasi -- Human experimental pain models 1 : the ultraviolet light UV-B pain model / James G. Modir and Mark S. Wallace -- Human experimental pain models 2 : the cold pressor model / James G. Modir and Mark S. Wallace -- Human experimental pain models 3 : heat/capsaicin sensitization and intradermal capsaicin models / James G. Modir and Mark S. Wallace -- The value of the dental impaction pain model in drug development / Stephen A. Cooper and Paul J. Desjardins -- Live cell imaging for studying G protein-coupled receptor activation in single cells / Deepak Kumar Saini and Narasimhan Gautam -- Recombinant cell lines stably expressing functional ion channels / Florian Steiner, Sraboni Ghose, and Urs Thomet -- Ion channels in analgesia research / Tamara Rosenbaum, Sidney A. Simon, and Leon D. Islas -- Electrophysiological and neurochemical techniques to investigate sensory neurons in analgesia research / Alexandru Babes [and others] -- The genetics of pain and analgesia in laboratory animals / William R. Lariviere and Jeffrey S. Mogil -- RT-PCR analysis of pain genes : use of gel-based RT-PCR for studying induced and tissue enriched gene expression / Kendall Mitchell and Michael J. Iadarola -- Gene-based approaches in the study of pathological pain / Elisa Dominguez, Alice Meunier, and Michel Pohl -- Linkage analysis and functional evaluation of inherited clinical pain conditions / Johannes J. Krupp, Dennis Hellgren, and Anders B. Eriksson -- Rat bone marrow stromal cells and oligonucleotides in pain research / María Florencia Coronel, Norma Alejandra Chasseing, and Marcelo José Villar -- Transplantation of human mesenchymal stem cells in the study of neuropathic pain / Dario Siniscalco -- Delivery of RNA interference to peripheral neurons in vivo using herpes simplex virus / Anna-Maria Anesti -- Combination of cell culture assays and knockout mouse analyses for the study of opioid partial agonism / Soichiro Ide [and others] -- Assessing potential functionality of cetechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders / Andrea G. Nackley and Luda Diatchenko -- Genetic polymorphisms and human sensitivity to opioid analgesics / Daisuke Nishizawa [and others] -- Molecular assays for characterization of alternatively spliced isoforms of the mu opioid receptor (MOR) / Pavel Gris [and others] -- Inhalational anesthetic photolabeling / Roderic G. Eckenhoff, Jin Xi, and William P. Dailey -- Measuring membrane protein interactions using optical biosensors / Joseph Rucker, Candice Davidoff, and Benjamin J. Doranz -- Proteomics and metabolomics and their application to analgesia research / Nichole A. Reisdorph and Richard Reisdorph -- Preemptive analgesia : problems with assessment of clinical significance / Igor Kissin -- Standardization of pain measurements in clinical trials / William K. Sietsema -- Procedural sedation and analgesia research / James R. Miner -- Non-invasive transcranial direct current stimulation for the study and treatment of neuropathic pain / Helena Knotkova and Ricardo A. Cruciani -- Pain imaging in the emerging era of molecular medicine / Christian S. Stohler and Jon-Kar Zubieta -- Current and emerging pharmacologic therapies for pain and challenges which still lay ahead / Christopher Noto and Marco Pappagallo Summary Chronic pain is a complex phenomenon, which continues to remain undertreated in the majority of affected patients thus representing a significant unmet medical need, but the development of cellular, subcellular, and molecular methods of approaching this epidemic of pain shows great promise. In Analgesia: Methods and Protocols, experts in the field present thorough coverage of molecular analgesia research methods from target discovery through target validation and clinical testing to tolerance and dependence, with extensive chapters on emerging receptor classes as targets for analgesic drugs and innovative analgesic strategies. As a volume in the highly successful Methods in Molecular Biology series, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes sections with tips on troubleshooting and avoiding known pitfalls. Comprehensive and essential, Analgesia: Methods and Protocols promises to aid and enrich the research of all those scientists and clinicians who are interested in what the increasingly molecular future has in store for analgesia research, from the molecular research bench through the animal laboratory to the bedside Analysis farmacologie pharmacology toxicologie toxicology pijn pain geneeskunde medicine farmacie pharmacy biomedische wetenschappen biomedicine Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes English Print version record Subject Analgesia. Chronic pain -- Treatment Chronic pain -- Molecular aspects Analgesics. Analgesics Models, Animal Investigative Techniques Sensory System Agents Central Nervous System Agents Peripheral Nervous System Agents Analytical, Diagnostic and Therapeutic Techniques and Equipment Therapeutic Uses Physiological Effects of Drugs Pharmacologic Actions Chemical Actions and Uses Chemicals and Drugs Analgesia Analgesics Analgesia Chronic pain -- Treatment Genre/Form Laboratory manuals Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Szallasi, Arpad, 1958- ISBN 9781603273237 1603273239

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