| Description |
1 online resource (vi, 391 pages) : illustrations |
| Series |
Current topics in microbiology and immunology, 0070-217X ; 316 |
|
Current topics in microbiology and immunology ; 316. 0070-217X
|
| Contents |
Refletions -- How to Chase a Red Herring and Come up with a Smallmouth Bass -- Interferon Research BC (Before Cloning) -- Purification and Cloning of Interferon Alpha -- Interferons and Their Signaling Pathways -- Type I Interferon: The Ever Unfolding Story -- The Receptor of the Type I Interferon Family -- IFN-?: Recent Advances in Understanding Regulation of Expression, Biological Functions, and Clinical Applications -- Cell Type-Specific Signaling in Response to Interferon-? -- Interferon Research: Impact on Understanding Transcriptional Control -- Recognition of Pathogens, Molecular Mechanism of Interferon Beta Induction -- TLR-Mediated Activation of Type I IFN During Antiviral Immune Responses: Fighting the Battle to Win the War -- Regulation of Antiviral Innate Immune Responses by RIG-I Family of RNA Helicases -- Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids -- Interferon-Induced Genes -- The Interferon-Stimulated Genes: Targets of Direct Signaling by Interferons, Double-Stranded RNA, and Viruses -- Structure and Function of the Protein Kinase R -- Virus Defense -- Viral Regulation and Evasion of the Host Response -- Pathogenic Viruses: Smart Manipulators of the Interferon System -- Role of Interferon in Viral Infection and Autoimmunity -- Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator -- Type I Interferon in Systemic Lupus Erythematosus |
| Summary |
Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a poorly defined protein of limited importance. The development of molecular techniques lead to the identification of a family of IFN genes and has shown an unexpected complexity of type I IFN genes and their expression. Presently, some aspects of the of the pathogen mediated induction of IFN gene expression are understood at molec |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer e-books |
| Subject |
Interferon.
|
|
Interferon Type I
|
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SCIENCE -- Life Sciences -- Anatomy & Physiology.
|
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Interferon.
|
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Biomédecine.
|
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Sciences de la vie.
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Interferon
|
| Form |
Electronic book
|
| Author |
Pitha, Paula M.
|
| LC no. |
72152360 |
| ISBN |
9783540713296 |
|
3540713298 |
|
9783540713289 |
|
354071328X |
|
