Title Vaccines for pandemic influenza / Richard W. Compans, Walter A. Orenstein, editors

Published Dordrecht ; New York : Springer, ©2009

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Description 1 online resource (xviii, 512 pages) : illustrations (some color) Series Current topics in microbiology and immunology, 0070-217X ; v. 333 Current topics in microbiology and immunology ; 333. Contents Pandemic influenza overview -- Pandemic influenza as a current threat -- Antigenic cross-reactivity among H5N1 Viruses --Current approaches for human and avian vaccine production -- Seasonal influenza vaccines -- Generation and characterization of candidate vaccine viruses for pre-pandemic influenza vaccines -- Live attenuated vaccines for pandemic influenza -- Influenza vaccines for avian species -- Development and application of avian influenza vaccines in China -- Novel vaccine approaches -- Designing vaccines for pandemic influenza -- Attenuated influenza virus vaccines with modified NS1 proteins -- DNA Vaccines against Influenza viruses -- Recombinant proteins produced in insect cells -- Influenza neuraminidase as a vaccine antigen -- Recombinant vectors as influenza vaccines -- Influenza virus-like particles as pandemic vaccines -- Pandemic influenza vaccines -- Adjuvants for pandemic influenza vaccines -- Novel Approaches of Vaccine Delivery -- Transcutaneous immunization with influenza vaccines -- Microneedle-based vaccines -- Vaccine evaluation, production and distribution -- Animal models for evaluation of influenza vaccines -- Immunosenescence and influenza vaccine efficacy -- Vaccines for pandemic influenza: summary of recent clinical trials -- Considerations for licensure of influenza vaccines with pandemic and pre-pandemic indications -- Strategies for broad global access to pandemic influenza -- Prioritization of pandemic influenza vaccine: rationale and strategy for decision-making Summary The recent outbreak of disease caused by a novel H1N1 virus has focused global attention on the threat of a new influenza pandemic. Recent years have also seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans resulting in numerous fatalities. The rapid expansion in the geographic distribution of these novel viruses raises the risk that such a virus could cause a global pandemic with high morbidity and mortality. An effective influenza vaccin Bibliography Includes bibliographical references and index Notes Print version record Subject Influenza vaccines. Epidemics. Influenza. Pandemics. Influenza Vaccines -- therapeutic use Disease Outbreaks Influenza, Human Alphainfluenzavirus Influenza Vaccines Epidemics Pandemics epidemics. pandemics. MEDICAL -- Preventive Medicine. MEDICAL -- Forensic Medicine. MEDICAL -- Public Health. Sciences de la vie. Biomédecine. Influenza Epidemics Influenza vaccines Form Electronic book Author Compans, Richard W. Orenstein, Walter A. ISBN 9783540921653 3540921656

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