| Description |
1 online resource (337 pages) |
| Contents |
Preface -- Contents -- Contributors -- Chapter 1: Mechanism of Action and Pharmacokinetics of Biologics -- Introduction -- Anti-TNFs -- Role of Tumor Necrosis Factor (TNF) in IBD -- Pharmacodynamics of Anti-TNFs -- Pharmacokinetics of Anti-TNFs -- Anti-integrins -- Pharmacodynamics of Vedolizumab -- Pharmacokinetics of Vedolizumab -- Anti-IL-12/23 -- Pharmacodynamics of Ustekinumab -- Pharmacokinetics of Ustekinumab -- Conclusions -- References -- Chapter 2: Antitumor Necrosis Factor Agents in Ulcerative Colitis -- Introduction |
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Indication for Use of TNFα Therapy in Ulcerative Colitis Goals of TNFα Therapy -- Anti-TNFα Agents -- Introduction -- Infliximab -- Induction and Maintenance Clinical Trials -- Long-Term Safety and Efficacy -- Adalimumab -- Induction and Maintenance Clinical Trials -- Long-Term Safety and Efficacy -- Golimumab -- Induction and Maintenance Clinical Trials -- Long-Term Safety and Efficacy Data -- Treating Adults Over the Age of 60 with Anti-TNFα Therapy -- General Monitoring for Safety and Efficacy of Anti-TNFα Agents |
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Choice of Anti-TNFα Agent to Treat UC Switching Anti-TNFα Therapies -- Patient Education -- Conclusion -- References -- Chapter 3: Antitumor Necrosis Factor Agents in Crohn#x80;#x99;s Disease -- Introduction -- Infliximab -- Clinical Efficacy -- Mucosal Healing -- Fistula Healing -- Adalimumab -- Clinical Efficacy -- Mucosal Healing -- Fistula Healing -- Certolizumab Pegol -- Clinical Efficacy -- Mucosal Healing -- Fistula Healing -- Pediatric Efficacy -- Top-Down or Step-Up -- Why Aren#x80;#x99;t All TNFs the Same? -- Conclusion |
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Predictors of Postoperative Recurrence Patient Factors -- Disease Factors -- Surgical Technique/Findings -- Prevention of Postoperative Recurrence -- Nonbiologic Treatment Options -- Biologics for Prevention of POR -- Methods to Treat Postoperative CD Recurrence -- Waiting for Recurrence -- Postoperative Prophylaxis -- Practical Strategies for Treating Postoperative Recurrence -- Future Research -- References -- Chapter 6: Biologics in Pregnancy and Breastfeeding -- Introduction -- Antitumor Necrosis Factor Agents |
| Summary |
This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn's disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease |
| Bibliography |
""References""""Chapter 4: Anti-TNF Therapy for Treatment of Extraintestinal Manifestations of Inflammatory Bowel Disease""; "" Peripheral Arthritis""; "" Axial Arthritis""; "" Uveitis""; "" Pyoderma Gangrenosum""; "" Erythema Nodosum""; "" Primary Sclerosing Cholangitis""; "" Bone Metabolism""; "" Conclusion""; ""References""; ""Chapter 5: Use of Biologics in the Postoperative Management of Crohn#x80;#x99;s Disease""; "" Burden of Postoperative Recurrence""; "" Detecting Postoperative Recurrence""; "" Endoscopy""; "" Fecal Calprotectin""; "" C-Reactive Protein""; "" Ultrasound"" |
| Notes |
"" Placental Transfer of Biologic Agents"" |
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Print version record |
| Subject |
Inflammatory bowel diseases -- Chemotherapy
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Biologicals.
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Biological products.
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Inflammatory Bowel Diseases -- drug therapy
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Biological Products -- therapeutic use
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Anti-Inflammatory Agents -- therapeutic use
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Biological Factors
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Biological Products
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HEALTH & FITNESS -- Holism.
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HEALTH & FITNESS -- Reference.
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MEDICAL -- Alternative Medicine.
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MEDICAL -- Atlases.
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MEDICAL -- Essays.
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MEDICAL -- Family & General Practice.
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MEDICAL -- Holistic Medicine.
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MEDICAL -- Osteopathy.
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Biological products
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Biologicals
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| Form |
Electronic book
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| Author |
Cheifetz, Adam S
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Feuerstein, Joseph D
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| ISBN |
9783319602769 |
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3319602764 |
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