| Description |
1 online resource : color illustrations |
| Contents |
Intro; Foreword; Foreword; Contents; Chapter 1: Fibrostenotic Inflammatory Bowel Disease: A Cinderella Story; References; Chapter 2: Epidemiology and Natural History of Fibrostenosing Inflammatory Bowel Disease; 2.1 Introduction; 2.2 Epidemiology of Fibrostenosing Inflammatory Bowel Disease; 2.2.1 Crohn's Disease; 2.2.2 Ulcerative Colitis; 2.3 Natural History of Fibrostenosing Inflammatory Bowel Disease; 2.3.1 Risk and Prognostic Factors Associated with Fibrostenosis in Crohn's Disease; 2.3.2 Clinical Manifestations and Disease Progression of Fibrostenosis in Crohn's Disease |
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2.3.3 Risk and Prognostic Factors Associated with Fibrostenosis in Ulcerative Colitis2.3.4 Clinical Manifestations and Disease Progression of Fibrostenosis in Ulcerative Colitis; 2.4 Pitfalls in Depicting Incidence and Natural History of Fibrostenosis Disease; References; Chapter 3: Genetic Influences on the Development of Fibrosis in Inflammatory Bowel Disease; 3.1 Introduction; 3.2 Genetics and Fibrosis in Crohn's Disease; 3.2.1 Bacterial Sensing; 3.2.1.1 Nucleotide-Binding Oligomerization Domain-Containing Protein 2, NOD2; 3.2.1.2 Toll-Like Receptors, TLRs |
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3.2.8 Other Processes3.3 The Combined Action of the Known Susceptibility Variants; 3.4 Genetics and Fibrosis in Paediatric CD; 3.5 Genetics and Fibrosis in Ulcerative Colitis; 3.6 Genetics and Fibrosis Around the World; 3.7 Clinical Implications of the Found Associations; 3.8 Conclusions and Future Directions; References; Chapter 4: Epigenetic Regulation of Intestinal Fibrosis; 4.1 Introduction; 4.2 Genetics; 4.3 Epigenetics; 4.4 Epigenetics and Fibrosis; 4.5 DNA Methylation; 4.6 DNA Methylation and Fibrosis; 4.7 Histone Modifications of DNA and Post-Translational Modifications of Proteins |
| Summary |
This book provides a comprehensive account of the pathogenesis and treatment of intestinal fibrosis, covering both the clinical and molecular aspects of the disease. It begins by describing the epidemiology and genetics of fibrostenosing IBD in Crohn's disease and Ulcerative colitis as well as the epigenetics and cellular and molecular mechanisms of the disease. Readers will obtain an in-depth overview of the disease from biomarkers and histology to surgical intervention, imaging and current and future drug therapies. Medical management of fibrosis, endoscopy and imaging as well as surgical approaches are all discussed. Through the links to videos contained in the book, the reader will become familiar with interventional procedures such as endoscopic balloon dilation and surgical techniques for stricturing IBD, such as resection and strictureplasties. This is an indispensable volume for anyone working on fibrostenotic IBD, such as gastroenterologists, internists, radiologists, colorectal surgeons, pathologists and researchers. It has been written by a team of top experts from North America, Asia and Europe |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed September 17, 2018) |
| Subject |
Inflammatory bowel diseases -- Pathogenesis
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Inflammatory bowel diseases -- Treatment
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Inflammatory Bowel Diseases -- etiology
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Fibrosis -- etiology
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Fibrosis -- therapy
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Inflammatory Bowel Diseases -- therapy
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Pathology.
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Surgery.
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Gastroenterology.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Inflammatory bowel diseases -- Treatment
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| Form |
Electronic book
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| Author |
Rieder, Florian, editor
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| ISBN |
9783319905785 |
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3319905783 |
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9783319905792 |
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3319905791 |
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9783030080464 |
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3030080463 |
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