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Title Kidney transplantation : strategies to prevent organ rejection / volume editors, Claudio Ronco, Stefano Chiaramonte, Giuseppe Remuzzi
Published Basel ; New York : Karger, ©2005


Description 1 online resource (viii, 155 pages) : illustrations
Series Contributions to nephrology, 0302-5144 ; v. 146
Contributions to nephrology ; v. 146. 0302-5144
Contents Renal transplantation / Cardillo, M., et al. -- Kidney transplantation in the hyperimmunized patient / Gloor, J. -- Chronic induction : what's new in the pipeline / Vincenti, F. -- Steroid or calcineurin-inhibitor sparing immunosuppressive protocols / Griny, J.M., Cruzado, J.M. -- Steroid-free lymphocyte depletion protocols : the potential for partial tolerance? / McCauley, J., Starzl, T.E. -- Chronic graft loss : immunological and non-immunological factors / Hernandez-Fuentes, M.P., Lechl, R.I. -- Lymphocyte depletion as a barrier to immunologic tolerance / Neujahr, D., Turka, L.A. -- Monitoring of immunosuppressive therapy in renal transplanted patients / Chiaramonte, S., Dissegna, D., Ronco, C. -- Chronic allograft nephropathy : a multiple approach to target nonimmunological factors / Ruggenenti, P. -- Transplantation tolerance : a complex scenario awaiting clinical applicability / Sayegh, M.H., Perico, N., Remuzzi, G. -- Dendritic cells, tolerance, and therapy of organ allograft rejection / Raimondi, G., Thomson, A.W. -- Natural versus adaptive regulatory T cells / Cassis, L., Aiello, S., Noris, M. -- Reviewing the mechanism of peripheral tolerance in clinical transplantation / Suciu-Foca, N., Cortesini, R. -- The goal of intragraft gene therapy / Tomasoni, S., Benigni, A
Summary Transplantation is today firmly established as the therapy of choice for end-stage organ failure. However, despite recent developments, this therapy is still not without challenges and risks: The necessity to take immunosuppressive drugs for the rest of one's life to prevent allograft rejection trades the morbidity and mortality of organ failure for the risks of infection and cancer as well as for an increased mortality from cardiovascular disease. Thus, there is an urgent need for optimizing the outcome of transplantation by achieving long-term, drug-free graft acceptance with normal organ function. Recently, numerous insights into the dynamic inter-relationship of host immune responses elicited by donor antigen presentation have substantially broadened our understanding of the cascade of events resulting in the acquisition of tolerance. With the pharmacopoeia of the transplant biologist continually expanding, the potential treatment combinations have become baffling and their impact on strategies to induce tolerance even more complex. This book presents novel insights into the pathways of acute rejection and their monitoring through molecular tests, new immunosuppressive agents currently under development as well as the most recent and promising approaches to induce tolerance that have emerged from experimental animal studies
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Current copyright fee: GBP36.40 24\0. Uk
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Kidneys -- Transplantation -- Complications
Graft rejection -- Prevention
Immunosuppresive agents
Kidney Transplantation -- immunology
Graft Rejection -- immunology
Graft Rejection -- prevention & control
Graft rejection -- Prevention.
Kidneys -- Transplantation -- Complications.
Nierentransplantation -- Transplantatabstossung -- Prävention -- Aufsatzsammlung.
Transplantatabstossung -- Prävention -- Nierentransplantation -- Aufsatzsammlung.
Form Electronic book
Author Ronco, C. (Claudio), 1951-
Chiaramonte, Stefano
Remuzzi, Giuseppe
S. Karger (Firm)
ISBN 9783318011685