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Book Cover
Author Nestlé Nutrition Workshop (64th : 2009 : Sydney, N.S.W.)

Title Microbial host-interaction : tolerance versus allergy / editors, Per Brandtzaeg, Erika Isolauri, Susan L. Prescott
Published Vevey, Switzerland : Nestec ; Basel, Switzerland ; New York : Karger, ©2009


Description 1 online resource (xvi, 271 pages) : illustrations
Series Nestlé nutrition workshop series. Pediatric program, 1661-6677 ; v. 64
Nestlé Nutrition workshop series. Paediatric programme ; v. 64.
Contents A paradigm for commensalism : the role of a specific microbial polysaccharide in health and disease / Kasper, D.L. -- The hygiene hypothesis : do we still believe in it? / Björkstén, B. -- 'ABC' of mucosal immunology / Brandtzaeg, P. -- Innate and adaptive immune pathways to tolerance / Thornton, C.A., Morgan, G. -- Hitting the mucosal road in tolerance induction / Wiedermann, U. -- Obesity : extending the hygiene hypothesis / Isolauri, E. [and others] -- Autoimmunity and diet / Cerf-Bensussan, N. -- Eosinophilic esophagitis : example of an emerging allergic manifestation? / Heine, R.G. -- Microbial-host interactions in inflammatory bowel diseases and experimental colitis / Sartor, R.B. -- Development and regulation of immune responses to food antigens in pre- and postnatal life / Renz, H. [and others] -- Novel approaches in treating food allergy using allergens / Rancé, F. -- Allergen avoidance approaches in food allergy management / Koletzko, S., Koletzko, B. -- Role of dietary immunomodulatory factors in the development of immune tolerance / Prescott, S.L. -- Microbial-host interactions : selecting the right probiotics and prebiotics for infants / Salminen, S. [and others] -- Probiotics and prebiotics : immunological and clinical effects in allergic disease / Tang, M.L.K. -- Modified proteins in allergy prevention / von Berg, A
Summary Most indigenous microbes occur in the intestinal tract, and their interactions with the host are largely unknown. Current understanding of host-microbe interactions links early microbial contact to the origin of disease, a theory that has its roots in the hygiene hypothesis. Modern life style appears to deprive the infant of conditions that provide adequate anti-inflammatory or tolerogenic stimuli upon antigen encounter. Thus, maturational signals from the environment and the diet are insufficient to adequately shape the immune system. This publication deals with the relationship between the gut microbiota as well as altered pattern of early microbial contact and the origin of human disease. New aspects of the original hygiene hypothesis are discussed in relation to disorders spanning from allergy and autoimmunity to obesity. The results presented suggest that all these disorders may be linked to aberrant antigen absorption and immune responses associated with dysfunction of mucosal defense. Researchers, clinicians and students interested in the interaction of the host with indigenous gut bacteria and the consequences for human health will find this publication of utmost interest
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Immunological tolerance -- Congresses
Host-parasite relationships -- Congresses
Food allergy -- Congresses
Gastric mucosa -- Congresses
Gastric mucosa.
Gastrointestinal Tract -- immunology
Gastrointestinal Tract -- microbiology
Gastric Mucosa
Host-Pathogen Interactions -- immunology
Hygiene Hypothesis
Life Style
Food allergy
Gastric mucosa
Host-parasite relationships
Immunological tolerance
Genre/Form Conference papers and proceedings
Form Electronic book
Author Brandtzaeg, Per
Isolauri, Erika
Prescott, Susan L
Nestlé Nutrition Institute.
S. Karger (Firm)
ISBN 9783805591683