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Title Vaccine adjuvants : methods and protocols / edited by Gwyn Davies
Published New York, NY : Humana Press, ©2010


Description 1 online resource (x, 314 pages) : illustrations
Series Springer protocols
Methods in molecular biology, 1064-3745 ; 626
Springer protocols (Series)
Methods in molecular biology (Clifton, N.J.) ; v. 626. 1064-3745
Contents Immunology of vaccine adjuvants / C.M.S. Ribeiro and V.E.J.C. Schijns -- Preclinical development of AS04 / N. Garçon -- Nonclinical safety assessment of vaccines and adjuvants / J.J. Wolf, C.V. Kaplanski and J.A. Lebron -- Aluminum adjuvants: Preparation, application, dosage, and formulation with antigen / E.B. Lindblad and N.E. Schønberg -- Freund's complete and incomplete adjuvants, preparation, and quality control standards for experimental laboratory animals use / D.E.S. Stewart-Tull -- Liposomal adjuvants: Preparation and formulation with antigens / J. Haensler -- Micro/nanoparticle adjuvants: Preparation and formulation with antigens / P. Malyala and M. Singh -- Adjuvant activity on human cells in vitro / D. Wit and M. Goldman -- Adjuvant activity on murine and human macrophages / V. Quesniaux, F. Erard and B. Ryffel -- In vitro effects of adjuvants on B cells / J. Vollmer and H. Bellert -- NKT cell responses to glycolipid activation / J.N. Tefit, G. Davies and V. Serra -- Tracking dendritic cells in vivo / C.M. Rush and J.M. Brewer -- Adjuvant effects on antibody titre / B. Walker and I. Feavers -- Functional antibody assays / I. Feavers and B. Walker -- Determining adjuvant activity on -cell function in vivo: Th cells / T. Lindenstrøm, P. Andersen and E.M. Agger -- Quantitative multiparameter assays to measure the effect of adjuvants on human antigen-specific CD8 t-cell responses / L. Derré [and others] -- Large-animal model for establishing E/T ratio of adjuvants / L.A.T. Hilgers -- Determining the activity of mucosal adjuvants / B.C. Baudner and G.D. Giudice -- Adjuvant activity of cytokines / M.G. Tovey and C. Lallemand
Summary Spanning from discoveries in fundamental immunology to industrial and commercial concerns, the study of vaccine adjuvants has developed into an exciting area of work with great, vital potential in innovating techniques in which adjuvants may steer the immune system towards the responses required by unmet vaccination needs. In Vaccine Adjuvants: Methods and Protocols, expert researchers in the field provide clear and concise guidance on how to go about assessing the activity of adjuvant products. Rather than describing individual adjuvants, the volume strives to include detailed, practical information on measuring the responses produced by adjuvants in order to be relevant to the widest array of experiments. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and versatile, Vaccine Adjuvants: Methods and Protocols will enable those already pursuing vaccine adjuvant research, while also serving to stimulate discussion on how to best standardize adjuvant testing in order to facilitate meaningful comparisons, and above all, to aid in the prediction of which new products will most effectively and safely help to solve the current challenges in vaccination
Analysis immunologie
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Immunological adjuvants -- Research
Immunological adjuvants -- Research -- Methodology
Adjuvants, Immunologic -- therapeutic use
Vaccines -- immunology
Microbiology & Immunology.
Health & Biological Sciences.
Form Electronic book
Author Davies, Gwyn, Ph. D.
LC no. 2009943283
ISBN 9781607615859