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Title Antibody engineering / edited by Carl A.K. Borrebaeck
Edition Second edition
Published New York : Oxford University Press, 1995


Location Call no. Vol. Availability
 W'PONDS  616.0793 Bor/Aen 1995  AVAILABLE
Description xv, 390 pages : illustrations ; 24 cm
Series Breakthroughs in molecular biology
Breakthroughs in molecular biology.
Contents 1. Antibody Structure and Function -- 2. Human Monoclonal Antibodies from V-Gene Repertoires Expressed on Bacteriophage -- 3. Synthetic Antibodies -- 4. Engineering the Antibody Combining Site by Codon-Based Mutagenesis in a Filamentous Phage Display System -- 5. Human Metaphoric Antibodies from a Phagemid Library -- 6. Stragies for Humanizing Antibodies -- 7. Single-Chain Fv Design and Production by Preparative Folding -- 8. Expressing Antibodies in Escherichia Coli -- 9. Vectors and Approaches for the Eukaryotic Expression of Antibodies and Antibody Fusion Proteins -- 10. The Cloning of Hybridoma V Regions for Their Ectopic Expression in Intracellular and Intercellular Immunization -- 11. The Expression of "Single Chain" Antibodies in Transgenic Plants
Summary As the field of antibody engineering continues its explosive growth, more and more scientists around the world are striving to keep up with the latest developments. Now in its second edition, Antibody Engineering is the perfect one-stop introduction to state-of-the-art technologies emerging in the field today. In presenting a practical overview of the engineering of recombinant human or mouse monoclonal antibodies, the book incisively addresses essential topics such as antibody structure relevant to engineering, recombinatorial cDNA libraries, phage display, synthetic and humanized antibodies, engineering of affinity and biological effector functions, and plant, mammalian, and bacterial expression vectors and hosts. Antibody Engineering, Second Edition - written by leading experts and now thoroughly updated - is a unique resource for current information on the subject. It will be welcomed by researchers in immunology, biotechnology, molecular biology, and biochemistry
Bibliography Includes bibliographical references and index
Subject Immunoglobulins -- Biotechnology.
Protein engineering.
Author Borrebaeck, Carl A. K., 1948-
LC no. 94025809
ISBN 0195091507