Title Immunoinformatics / edited by Rajat K. De, Namrata Tomar

Edition Second edition Published New York : Humana Press, [2014] ©2014

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Description 1 online resource (xix, 586 pages) : illustrations (chiefly color) Series Methods in molecular biology, 1940-6029 ; Volume No. 1184 Methods in molecular biology (Clifton, N.J.) ; v. 1184. 1064-3745 Contents PART I. IMMUNOINFORMATICS: TRANSITION FROM BASIC BIOLOGY TO INFORMATICS -- 1. A Brief Outline of the Immune System / Namrata Tomar and Rajat K. De -- 2. Cross Talk Between the Metabolic and Immune Systems / Namrata Tomar and Rajat K. De -- 3. Immunoinformatics: A Brief Review / Namrata Tomar and Rajat K. De PART II. DATABASES -- 4. Immunoinformatics of the V, C, and G Domains: IMGT® Definitive System for IG, TR and IgSF, MH, and MhSF / Marie-Paule Lefranc -- 5. IMGT/HLA and the Immuno Polymorphism Database / James Robinson, Jason A. Halliwell, and Steven G.E. Marsh -- 6. Databases for T-Cell Epitopes / Chun-Wei Tung -- 7. Databases for B-Cell Epitopes / Juan Liu and Wen Zhang -- 8. Antigen-Antibody Interaction Database (AgAbDb): A Compendium of Antigen-Antibody Interactions / Urmila Kulkarni-Kale, Snehal Raskar-Renuse, Girija Natekar-Kalantre, and Smita A. Saxena -- 9. Allergen Databases / Gaurab Sircar, Debasree Sarkar, Swati Gupta Bhattacharya, and Sudipto Saha PART III. TOOLS FOR PREDICTION -- 10. Prediction of Conformational B-Cell Epitopes / Wen Zhang, Yanqing Niu, Yi Xiong, and Meng Ke -- 11. Computational Prediction of B Cell Epitopes from Antigen Sequences / Jianzhao Gao and Lukasz Kurgan -- 12. Machine Learning-Based Methods for Prediction of Linear B-Cell Epitopes / Hsin-Wei Wang and Tun-Wen Pai -- 13. Mimotope-Based Prediction of B-Cell Epitopes / Jian Huang, Bifang He, and Peng Zhou -- 14. Hybrid Methods for B-Cell Epitope Prediction / Salvador Eugenio C. Caoili -- 15. Building Classifier Ensembles for B-Cell Epitope Prediction / Yasser EL-Manzalawy and Vasant Honavar -- 16. Multiplex Peptide-Based B Cell Epitope Mapping / Sanne M.M. Hensen, Merel Derksen, and Ger J.M. Pruijn -- 17. Classification of Human Leukocyte Antigen (HLA) Supertypes / Mingjun Wang and Mogens H. Claesson -- 18. Customized Predictions of Peptide-MHC Binding and T-Cell Epitopes Using EPIMHC / Magdalena Molero-Abraham, Esther M. Lafuente, and Pedro Reche -- 19. T-Cell Epitope Prediction Methods: An Overview / Dattatraya V. Desai and Urmila Kulkarni-Kale -- 20. Computational Antigenic Epitope Prediction by Calculating Electrostatic Desolvation Penalties of Protein Surfaces / Sébastien Fiorucci and Martin Zacharias -- 21. In Silico Prediction of Allergenic Proteins / Gaurab Sircar, Bodhisattwa Saha, Swati Gupta Bhattacharya, and Sudipto Saha -- 22. Prediction of Virulence Factors Using Bioinformatics Approaches / Rupanjali Chaudhuri and Srinivasan Ramachandran PART IV. SYSTEMS BIOLOGY APPROACHES IN IMMUNOINFORMATICS -- 23. A Systems Biology Approach to Study Systemic Inflammation / Bor-Sen Chen and Chia-Chou Wu -- 24. Procedures for Mucosal Immunization and Analyses of Cellular Immune Response to Candidate HIV Vaccines in Murine and Nonhuman Primate Models / Shailbala Singh, Pramod Nehete, Patrick Hanley, Bharti Nehete, Guojun Yang, Hong He, Scott M. Anthony, Kimberly S. Schluns, and K. Jagannadha Sastry -- 25. Immunoinformatics and Systems Biology in Personalized Medicine / Guillermo Lopez-Campos, Jesús F. Bermejo-Martin, Raquel Almansa, and Fernando Martin-Sanchez PART V. APPLICATIONS OF IMMUNOINFORMATICS -- 26. The Role of Small RNAs in Vaccination / Ajeet Chaudhary and Sunil Kumar Mukherjee -- 27. Structure-Based Clustering of Major Histocompatibility Complex (MHC) Proteins for Broad-Based T-Cell Vaccine Design / Joo Chuan Tong, Tin Wee Tan, and Shoba Ranganathan -- 28. Immunoinformatics, Molecular Modeling, and Cancer Vaccine / Seema Mishra and Subrata Sinha -- 29. Investigating Host-Pathogen Behavior and Their Interaction Using Genome-Scale Metabolic Network Models / Priyanka P. Sadhukhan and Anu Raghunathan -- 30. Mathematical Models of HIV Replication and Pathogenesis / Dominik Wodarz Summary "Content and General Outline of the Book. We have tried to make this edition of the book self-contained. In principle, it aims at students and researchers from diverse background and levels interested in working with immunological problems. It provides biological insights into a certain extent as well as a simpler way to implement approaches and algorithms in the immunoinformatics research domain. There are 30 chapters distributed in five sections that cover various aspects of basic immunology to immunoinformatics. Part I is dedicated to describing the transition from basic and traditional immunology to immunoinformatics. It includes three chapters that introduce a basic immune system, its interaction with metabolic machinery, and informatics related to immune system. Part II contains comprehensive detail on most of the existing databases related to an immune system and its components. Similarly, most of the possible approaches/tools/algorithms for the prediction of T/B-cell epitopes, allergenic proteins, and virulence factors are described in Part III. In Part IV, systems biology approaches in the immunoinformatics domain have been explained, particularly for inflammation and personalized medicine. Part V deals with some applications of immunoinformatics research. In this section, we have provided applications of immunoinformatics in cancer diagnosis and therapy, HIV pathogenesis, and methods to investigate the mechanisms of host-pathogen interactions. Part V also includes the description of the role of structure-based clustering of MHC molecules as well as small RNA in vaccine designing."--Preface, page viii Analysis biomedische wetenschappen biomedicine immunologie immunology Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes Online resource. (Springer Protocols, viewed on September 11, 2014) Subject Immunoinformatics. Immunology. Computational biology. Bioinformatics. Immune system. Systems biology. Allergy and Immunology Informatics Computational Biology Immune System Systems Biology Immune System Phenomena Systems biology Immune system Computational biology Bioinformatics Immunoinformatics Immunology Genre/Form Laboratory manuals Laboratory manuals. Manuels de laboratoire. Form Electronic book Author De, Rajat K., editor Tomar, Namrata, editor LC no. 2014942969 ISBN 9781493911158 1493911155 1493911147 9781493911141

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