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Title Natural antibodies : methods and protocols / edited by Srinivas V. Kaveri, Jagadeesh Bayry
Published New York, NY : Humana Press, 2017


Description 1 online resource (xi, 199 pages) : illustrations (some color)
Series Methods in molecular biology, 1064-3745 ; volume 1643
Methods in molecular biology (Clifton, N.J.) ; v. 1643, 1064-3745
Contents Natural Antibodies: Next Steps towards Translational Investigation -- Isolation of Natural Anti-FceRIa Autoantibodies from Healthy Donors -- Isolation of Antibodies from Human Plasma, Saliva, Breast Milk, and Gastrointestinal Fluid -- Purification of Natural Antibodies against Tau Protein by Affinity Chromatography -- Unbiased RACE-Based Massive Parallel Surveys of Human IgA Antibody Repertoires -- Analysis of Signaling Events in B-1a Cells -- Exploring the Role of Microbiota in the Limiting of B1 and MZ B-Cell Numbers by Naturally-Secreted Immunoglobulins -- Assessment of Anti-Tumor Cytotoxic Activity of Naturally Occurring Antibodies in Human Serum or Plasma -- Hydrolysis and Dissolution of Amyloids by Catabodies -- Methods for Post-Translational Induction of Polyreactivity of Antibodies -- Characterization of Natural IgM Antibodies Recognizing Oxidation-Specific Epitopes on Circulating Microvesicles -- Natural Monoclonal Antibody to Oxidized Low-Density Lipoprotein and Aggregatibacter actinomycetemcomitans -- Detection of Natural Antibodies and Serological Diagnosis of Pneumococcal Pneumonia using a Bead-Based High-Throughput Assay -- Detection of Naturally Occurring Human Antibodies against Gangliosides by ELISA -- Evaluating the Impact of Natural IgM on Adenovirus Type 5 Gene Therapy Vectors
Summary This volume looks at the role of natural antibodies in pathogen elimination, cell survival, inflammation, cancer, and autoimmunity. The chapters in this book cover numerous topics, such as isolation of natural antibodies; methods for separating natural antibodies from human plasma, saliva, breast milk, and gastrointestinal fluids; functional properties of natural antibodies such as anti-tumor cytotoxic activity, and hydrolysis and dissolution of their target antigens; their utility in serological diagnosis of microbial antigens; and the role of natural antibodies in inhibiting viral vectors in the absence of prior exposure to the virus
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed July 6, 2017)
Subject Immunoglobulins -- Laboratory manuals
Natural immunity -- Laboratory manuals
Serum Globulins
Medical -- Immunology.
Natural immunity
Genre/Form Laboratory manuals
Laboratory manuals.
Form Electronic book
Author Kaveri, Srini V., editor.
Bayry, Jagadeesh, editor.
LC no. 2017943968
ISBN 9781493971800