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Book Cover

Title Antibody expression and production / edited by Mohamed Al-Rubeai
Published Dordrecht ; New York : Springer, 2011


Description 1 online resource (ix, 345 pages) : illustrations
Series Cell engineering ; 7
Cell engineering ; 7.
Contents Expression of antibody in mammalian cells -- Bioreactor systems for producing antibody from mammalian cells -- Production of antibody in insect cells -- Production of monoclonal antibodies in glycoengineered Pichia pastoris -- Production of antibodies in Hansenula polymorpha -- Production of antibody by transgenic avians -- Production of antibodies in plants -- Production of antibody fab fragments in Escherichia coli -- Intrabody expression in mammalian cells -- Engineering antibodies for cancer therapy -- Recombinant bispecific antibodies for cancer therapy -- The Role of glycosylation in therapeutic antibodies -- Quality issues arising from post-translational modification of recombinant antibodies -- Recovery and purification of antibody
Summary Engineered antibodies currently represent over 30 per cent of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in
Analysis biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Immunoglobulins.
Immunoglobulins -- Biotechnology
Immunoglobulins -- Biotechnology.
Form Electronic book
Author Al-Rubeai, Mohamed, 1948-
ISBN 9789400712577