Title The immunoglobulins : structure and function / Roald Nezlin

Published San Diego : Academic Press, 1998

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Description 1 online resource (xiii, 269 pages) : illustrations (some color) Contents General characteristics of immunoglobulin molecules -- Animal and human immunoglobulins -- Engineering antibody molecules -- Antigen-combining site -- Antigen-recognizing molecules other than antibodies -- Interactions outside the antigen-combining site -- Segmental movements of immunoglobulin molecules Summary This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem. Key Features * Describes recent reviews on the structure and function of immunoglobulin molecules of various species * Summarizes in detail recent findings on the fine structure of the antigen-combining site * Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors * Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens * Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties * Presents extensive references and is lavishly illustrated Bibliography Includes bibliographical references and index Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL Print version record digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Subject Immunoglobulins. Immunoglobulins Serum Globulins MEDICAL -- Immunology. Immunoglobulins Immunglobuline Form Electronic book ISBN 9780125179706 0125179707 9780080534527 008053452X

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