| Description |
1 online resource (xi, 311 pages) : illustrations (some color) |
| Contents |
Preface; Acknowledgements; Contents; Part I: General Remarks; Chapter 1: IgG4-Related Disease: History and Overview; 1.1 Introduction; 1.2 Concept of IgG4-Related Disease; 1.3 Epidemiology; 1.4 History; 1.4.1 Mikuliczś Disease and Autoimmune Pancreatitis; 1.4.2 Autoimmune Pancreatitis and IgG4; 1.4.3 Extra-Pancreatic Manifestations of Autoimmune Pancreatitis and the Proposal of IgG4-Related Disease; 1.5 Nomenclature of IgG4-Related Disease; 1.6 Diagnosis of IgG4-Related Disease; 1.7 Clinical Features of IgG4-Related Disease Outside of the Urinary System |
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1.7.1 IgG4-Related Dacryoadenitis and Sialadenitis1.7.2 IgG4-Related Respiratory Disease; 1.7.3 IgG4-Related Sclerosing Cholangitis; 1.7.4 IgG4-Related Retroperitoneal Fibrosis; 1.7.5 IgG4-Related Disease in the Central Nervous System; 1.7.6 IgG4-Related Thyroiditis; 1.7.7 IgG4-Related Hepatopathy; 1.7.8 Other IgG4-Related Diseases; 1.8 Prognosis of IgG4-Related Disease; 1.8.1 Complications of Malignancy; 1.8.2 Chronic State Showing Functional Insufficiency; References; Chapter 2: IgG4-Related Disease: Pathological Features and Differential Diagnosis; 2.1 Introduction |
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2.2 General Rules for the Pathology of IgG4-RD2.3 Sialadenitis and Dacryoadenitis; 2.4 Lung Disease; 2.5 Pancreatitis; 2.6 Hepatobiliary Manifestations; 2.7 Periaortitis and Periarteritis; 2.8 Biopsy Diagnosis; 2.9 Summary; References; Chapter 3: Potential Pathways in the Pathogenesis of IgG4-Related Disease; 3.1 Introduction; 3.2 Th Subsets in IgG4-RD; 3.2.1 Th1/Th2 Balance; 3.2.2 Treg Cells; 3.2.3 Th17 Cells; 3.2.4 Tfh Cells; 3.2.5 CD4+CTL Cells; 3.3 Innate Immunity; 3.4 Conclusions; References; Chapter 4: Does IgG4-Related Disease Have an Autoimmune Basis?; 4.1 Introduction |
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4.2 Autoantibodies4.3 Autoimmune Diseases and IgG4; 4.3.1 IgG4-RD and Autoimmune Diseases; 4.3.2 IgG4 in Autoimmune Diseases; 4.4 Immune Complexes; 4.4.1 Immune Complexes in IgG4-Related Tubulointerstitial Nephritis; 4.4.2 Immune Complexes in the Glomerular Lesions in IgG4-RD; 4.4.3 Complement in IgG4-Related TIN; 4.5 Does IgG4-Related Disease Have an Autoimmune Basis?; References; Chapter 5: Plasmablasts: A Promising Biomarker in IgG4-Related Disease; 5.1 Introduction; 5.2 What Is a Plasmablast? The Origins and Biologic Functions of This Cell |
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5.3 Identification of Plasmablasts by Flow Cytometry5.4 Plasmablasts in IgG4-Related Disease; References; Part II: Features of IgG4-Related Kidney Disease and Associated Conditions; Chapter 6: Overview of IgG4-Related Kidney Disease; 6.1 Tubulointerstitial Nephritis Before IgG4-Related Disease; 6.2 Renal Involvement in IgG4-RD; 6.3 Establishment of the Disease Concept of IgG4-RKD; 6.4 Epidemiology; 6.5 Characteristic Features; 6.6 Urological Aspects; 6.7 Conclusion; References; Chapter 7: IgG4-Related Kidney Disease: Clinical and Laboratory Features; 7.1 Clinical Features of IgG4-RKD |
| Summary |
This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in IgG4-RD have been reported and are recently attracting attention as IgG4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of IgG4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of IgG4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. IgG4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields |
| Bibliography |
Includes bibliographical references at the end of each chapters |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 22, 2016) |
| Subject |
Kidneys -- Diseases -- Immunological aspects
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Immunoglobulin G.
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Kidneys -- Diseases.
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Kidney Diseases
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Immunoglobulin G
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Kidneys -- Diseases
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Immunoglobulin G
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Kidneys -- Diseases -- Immunological aspects
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| Form |
Electronic book
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| Author |
Saito, Takao, editor
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Stone, John H., editor
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Nakashima, Hitoshi, editor
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Saeki, Takako, editor
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Kawano, Mitsuhiro, editor.
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| ISBN |
9784431556879 |
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4431556877 |
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