Title Antibody therapeutics / edited by William J. Harris, John R. Adair

Published Boca Raton, Fla. : CRC Press, 1997

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Description 1 online resource (366 pages) : illustrations Series Pharmacology and toxicology Pharmacology & toxicology (Boca Raton, Fla.) Contents pt. 1. Antibodies as therapeutics. Unconjugated antibodies as therapeutics / M. Clark -- Immunotoxins for treating cancer and autoimmune disease / R.J. Kreitman and I. Pastan -- Antibodies as carriers for drugs and radioisotopes / G. Yarranton -- Tumor targeting by antibody-drug conjugates / I. Benhar and I. Pastan -- pt. 2. Application of antibody therapeutics. Therapeutic antibodies in infectious disease / W.J. Harris -- Antibody therapeutics: application to autoimmunity / L. Chatenoud -- Monoclonal antibodies in transplantation / M.-L. Alegre -- pt. 3. Development of antibody therapeutics. Regulatory issues for the development of antibody therapeutics / K.J. Lambert -- Manufacture of antibodies by large-scale mammalian cell culture / D.K. Robinson, V. Yabannavar and Y. Deo -- Production of antibody domains in prokaryotes / M. Better and P. Gavit -- Emerging production systems for antibody therapeutics / A.J.R. Porter, K.J. Bentley, P.M. Cupit and T.P. Wallace -- pt. 4. Recombinant antibodies in the clinic. Development of Zenapax: a humanized anti-tac antibody / J. Hakimi ... et al. -- Progress with a reshaped human monoclonal antibody, RSHZ19, for the prophylaxis and treatment of respiratory syncytial virus infection / S.B. Dillon and T.G. Porter -- CDP571, an engineered antibody to human tumor necrosis factor / S. Stephens, O. Vetterlein and M. Sopwith -- The therapeutic potential of a Primatized, nondepleting anti-CD4 (IDEC-CE9.1) monoclonal antibody / A.M. Solinger ... et al Summary Published in 1997: Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading for researchers, clinicians, development and regulatory staff in pharmaceutical and biotechnology companies, and hospital staff, including policy and decision makers. It also provides postgraduate and medical students with an authoritative overview of the field Bibliography Includes bibliographical references and index Notes William J. Harris, Ph. D., C. Biol, is Professor of Genetics at the University of Aberdeen, Scotland. John R. Adair, Ph. D., is Product Development Manager at Axis Genetics, Plc Print version record Subject Immunoglobulins -- Therapeutic use Monoclonal antibodies -- Therapeutic use Antibodies, Monoclonal -- therapeutic use MEDICAL -- Pharmacology. MEDICAL -- Toxicology. MEDICAL -- Immunology. Immunoglobulins -- Therapeutic use Monoclonal antibodies -- Therapeutic use Immuntherapie Aufsatzsammlung Monoklonaler Antikörper Antikörper Form Electronic book Author Harris, William J Adair, John R ISBN 9780429260360 0429260369 9780429535987 0429535988 9780429550683 0429550685 9780429522512 0429522517

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