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Title Immunogenomics and human disease / [edited by] András Falus
Published Chichester, West Sussex, England ; Hoboken, NJ : John Wiley, ©2006
Online access available from:
Wiley Online Books    View Resource Record  


Description 1 online resource (xxi, 526 pages) : illustrations (some color)
Contents Cover Contents Preface List of Contributors 1 Genotyping methods and disease gene identification 1.1 Introduction 1.2 Genotyping of single-nucleotide polymorphisms 1.3 Methods for interrogating SNPs 1.4 Analysis formats 1.5 The current generation of methods for SNP genotyping 1.6 The next generation 1.7 Classical HLA typing 1.8 MHC haplotypes 1.9 Molecular haplotyping 1.10 Microhaplotyping 1.11 MHC and disease associations 1.12 Conclusions Acknowledgements References 2 Glycomics and the sugar code: primer to their structural basis and functionality 2.1 Introduction 2.2 Lectins as effectors in functional glycomics 2.3 Galectins: structural principles and intrafamily diversity 2.4 Ligand-dependent levels of affinity regulation 2.5 Perspectives for galectin-dependent medical applications 2.6 Conclusions References 3 Proteomics in clinical research: perspectives and expectations 3.1 Introduction 3.2 Proteomics: tools and projects 3.3 Discussion 3.4 Concluding remarks Acknowledgements References 4 Chemical genomics: bridging the gap between novel targets and small molecule drug candidates. Contribution to immunology 4.1 Introduction of chemical genomics: definitions 4.2 Chemical microarrays 4.3 Small molecule and peptide probes for studying binding interactions through creating a covalent bond 4.4 Photochemical proteomics 4.5 General aspects of photoaffinity labelling 4.6 Photoreactive probes of biomolecules 4.7 Application to the immunobiology of living cells 4.8 Multifunctional photoprobes for rapid analysis and screening 4.9 Advanced application to functional proteomics 4.10 Summary References 5 Genomic and proteomic analysis of activated human monocytes 5.1 Primary human monocytes, as a model system 5.2 Transcriptional profiling of activated monocytes 5.3 Functional genomics 5.4 Proteomic analysis of activated human monocytes References 6 Bioinformatics as a problem of knowledge representation: applications to some aspects of immunoregulation 6.1 Introduction 6.2 Sequences and languages 6.3 Three-dimensional models 6.4 Genomes, proteomes, networks 6.5 Computational tools 6.6 Information processing in the immune system 6.7 Concluding remarks References 7 Immune responsiveness of human tumours 7.1 Introduction 7.2 Defining tumour immune responsiveness 7.3 Studying immune responsiveness in human tumours 7.4 Immune responsiveness in the context of therapy 7.5 The spatial dimension in the quest for the target 7.6 Studying the receiving end tumour as an elusive target for immune recognition 7.7 The role of the host in determining immune responsiveness 7.8 Concluding remarks References 8 Chemokines regulate leukocyte trafficking and organ-specific metastasis 8.1 Chemokines and chemokine receptors 8.2 Chemokine receptors in the organ-specific recruitment of tumour cells 8.3 Cancer therapy using chemokine receptor inhibitors 8.4 Conclusions References 9 Towards a unified approach to new target discovery in breast cancer: combining the power of genomics, proteomics and immunology 9.1 Introduction 9.2 The use of CGH and DNA microarray-based transcriptional profiling for new target discovery in breast cancer 9.3 The challenge of new tumour marker/target validation: traditional techniques meet new proteomics tools 9.4 Immunological validation of new target genes in breast cancer: the emerging concept of the cancer immunome 9.5 Future prospects: combining target discovery approaches in unified publicly accessible databases References 10 Genomics and functional differences of dendritic cell subsets 10.1 Introduction 10.2 Origin, differentiation and function of human dendritic cell subsets 10.3 Tissue localization of dendritic cell subsets 10.4 Antigen uptake by dentritic cells 10.5 Antigen processing and presentation by dendritic cells 10.6 Activation and polarization of dendritic cells 10.7 Enhancement of inflammatory responses by NK cells 10.8 Suppression of
Summary Provides an overview of key conceptual and molecular technologies being deployed in immunogenomics. This book features the evaluations of the impact of genomics and systems biology on important areas such as cancer immunology, autoimmunity, allergy and the response to infection
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Immunogenetics.
Genetics -- Technique.
Immunogenetics -- methods
Genetic Techniques
Genomics -- methods
Immunity -- genetics
MEDICAL -- Immunology.
Genetics -- Technique
Form Electronic book
Author Falus, András.
ISBN 9780470033241