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Book Cover
Author Wong, Shan S

Title Chemistry of protein and nucleic acid cross-linking and conjugation / Shan S. Wong, David M. Jameson
Edition 2nd ed
Published Boca Raton : CRC Press, 2012


Description 1 online resource (xvii, 602, [2] pages of plates) : illustrations (some color)
Contents 880-01 Ch. 1. Overview of protein conjugation -- ch. 2. Review of protein and nucleic acid chemistry -- ch. 3. Reagents targeted to specific functional groups -- ch. 4. How to design and choose cross-linking reagents -- ch. 5. Homobifunctional cross-linking reagents -- ch. 6. Heterobifunctional cross-linkers -- ch. 7. Multifunctional cross-linking reagents -- ch. 8. Monofunctional and zero-length cross-linking reagents -- ch. 9. General approaches for chemical cross-linking -- ch. 10. Analysis of cross-linked products -- ch. 11. Applications of chemical cross-linking to the study of biological macromolecules -- ch. 12. Applications of chemical conjugation in the preparation of immunoconjugates and immunogens -- ch. 13. Application of chemical conjugation for the preparation of immunotoxins and other drug conjugates for targeting theraputics -- ch. 14. Application of chemical conjugation to solid-state chemistry
880-01/(N Front Cover -- Contents -- Preface -- Authors -- Chapter 1: Overview of Protein Conjugation -- Chapter 2: Review of Protein and Nucleic Acid Chemistry -- Chapter 3: Reagents Targeted to Specific Functional Groups -- Chapter 4: How to Design and Choose Cross-Linking Reagents -- Homobifunctional Cross-Linking Reagents -- Chapter 6: Heterobifunctional Cross-Linkers -- Chapter 7: Multifunctional Cross-Linking Reagents -- Chapter 8: Monofunctional and Zero -Length Cross -Linking Reagents -- Chapter 9: General Approaches for Chemical Cross-Linking -- Chapter 10: Analysis of Cross-Linked Products -- Chapter 11: Applications of Chemical Cross-Linking to the Study of Biological Macromolecules -- Chapter 12: Applications of Chemical Conjugation in the Preparation of Immunoconjugates and Immunogens -- Chapter 13: Application of Chemical Conjugation for the Preparation of Immunotoxins and Other Drug Conjugates for Targeting Therapeutics -- Chapter 14: Application of Chemical Conjugation to Solid-State Chemistry -- Appendix Ађ́ёAmino Group-Directed Homobifunctional Cross-Linkers -- Appendix Вђ́ёSulfhydryl Group-Directed Homobifunctional Cross-Linkers -- Appendix Сђ́ёPhenolate- and Imidazolyl-Group-Directed Reagents: Bisdiazonium Precursors -- Appendix Dђ́ёGroup Selective Heterobifunctional Cross-Linkers -- Appendix Еђ́ёPhotoactivatable Heterobifunctional Cross-Linking Reagents -- Back Cover
Summary Since the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross-linking reagents, and advances have also been made in the area of biosensors and microarray biochips for the detection and analysis of genes, proteins, and carbohydrates. In addition, developments in physical techniques with unprecedented sensitivit
Notes Revised edition of: Chemistry of protein conjugation and cross-linking. c1991
Bibliography Includes bibliographical references and index
Subject Proteins -- Crosslinking.
Proteins -- chemistry
Cross-Linking Reagents
Immunoconjugates -- chemistry
Immunoconjugates -- therapeutic use
Nucleic Acids -- chemistry
Proteins -- Crosslinking.
Konjugiertes System
Form Electronic book
Author Jameson, David M
Wong, Shan S. Chemistry of protein conjugation and cross-linking
ISBN 9781420007640