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Author Bins, Adriaan Dirk.

Title Induction and analysis of antigen-specific T cell responses in melanoma patients and animal models / Adriaan Dirk Bins
Edition Second edition
Published [Leiden] : Leiden University Press, [2007]
Online access available from:
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Description 1 online resource (148 pages) : illustrations (some color)
Contents Introduction; Ch. 1: On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients.; Ch. 2:Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GM-CSF in advanced-stage HLA-A*0201- positive melanoma patients.; Ch. 3: A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression; Ch. 4:Superior immunogenicity of DNA tattooing as compared to intramuscular DNA vaccination in non-human primates.; Ch. 5: In vivo antigen stability affects vaccine efficacy
Summary In the last century, it has become clear that in patients suffering certain types of cancer, spontaneous activation of the immune sytem may lead to curation. The concept of immunotherapy is based on that notion. The intention is to stimulate T cells direc
Notes Proefschrift--Universiteit Leiden, 2007
Bibliography Includes bibliographical references
Notes Summary in Dutch
Print version record
Subject Cancer vaccines -- Research.
Immunocompetent cells -- Research.
Melanoma -- Immunological aspects -- Research.
T cells -- Research.
Genre/Form Academic theses.
Form Electronic book
ISBN 9048505917 (electronic bk.)
9789048505913 (electronic bk.)