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Title Management of infections in the immunocompromised host / Brahm H. Segal, editor
Published Cham : Springer, [2018]


Description 1 online resource : color illustrations
Contents 880-01 Intro; Dedication; Preface; Contents; Contributors; 1: Phagocytes; Origin and Development of Phagocytes; Mononuclear Phagocytes; Granulocytes; Recruitment, Chemotaxis, and Priming; Rolling; Priming; Adhesion; Transendothelial Cell Migration; Phagocytosis and Microbicidal Activity; Phagocytosis; Maturation of Phagosomes; Production of Reactive Oxygen Species; Production of Reactive Nitrogen Species; Oxygen-Independent Antimicrobial Systems; Extracellular Traps (ETs); Antigen Presentation; Concluding Comments; References; 2: T Cell Immunity; Introduction; Origin and Development of T Cells
880-01/(S α-Helical AMPs
Immunodeficiency in the Absence of B CellsSummary; References; 4: Complement; The Complement System; Historical Aspects; Evolution of the Complement System; Synthesis, Distribution, and Catabolism of Complement; Activation of Complement; The Classical Pathway; The Lectin Pathway; The Alternative Pathway; C3: The Central Component of Complement; Activation of the Alternative Pathway; The "Tickover" Model; The Properdin-Directed Model; The Terminal Complement Pathway: Assembly of the Membrane Attack Complex; The Intracellular Complement System; Inhibition of Complement Activation
Fluid-Phase Complement InhibitorsC1 Inhibitor (C1-INH); Factor I; C4b-Binding Protein (C4BP); Factor H (FH) and the FH Family of Proteins; Vitronectin (Vn); Clusterin (Cn); Membrane-Associated Complement Inhibitors; Complement Receptor 1 (CR1; Also Called CD35 or the Immune Adherence Receptor); CD46 (Membrane Cofactor Protein or MCP); CD55 (Decay-Accelerating Factor [DAF]); CD59 (Homologous Restriction Factor 20 (HRF-20), Membrane Attack Complex Inhibitory Factor (MACIF), or Protectin); Complement Receptor of the Immunoglobulin Superfamily (CRIg); Complement Receptors
Summary This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in the field and future directions of research. This book begins with an overview of the normally functioning immune system followed by a detailed discussion of the major primary immunodeficiencies. Specific chapters are dedicated to providing practical knowledge in the prevention and treatment of infections in specific immunocompromised patients, including those with cancer, transplant recipients, HIV infection, and autoimmune disorders. Emphasis is placed on diagnostic evaluation, antimicrobial selection that includes consideration of the threat of antimicrobial-resistant pathogens, and immunotherapy tailored to specific patients. Finally, dedicated chapters on stem cell transplantation for patients with primary immunodeficiencies, adoptive cellular immunotherapy, and gene therapy will provide readers with insight into these rapidly evolving and cutting edge therapies. Management of Infections in the Immunocompromised Host is a valuable resource for infectious diseases specialists, immunologists, oncologists, hematologists, general physicians, students, researchers, and all other working with immunocompromised patients
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed June 25, 2018)
Subject Immunologic diseases.
Infection -- Immunological aspects
Infection -- Treatment
Public health.
Communicable diseases.
Public Health
Communicable Diseases
Immune System Diseases
public health.
Accident & emergency medicine.
General practice.
Infectious & contagious diseases.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Public health
Communicable diseases
Immunologic diseases
Infection -- Immunological aspects
Infection -- Treatment
Form Electronic book
Author Segal, Brahm H., editor.
ISBN 9783319776743