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Title Immunosenescence / [edited by] Graham Pawelec
Published Austin, Tex. : Landes Bioscience ; New York, N.Y. : Springer Science+Business Media, ©2007

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Description 1 online resource (194 pages) : illustrations
Series Medical intelligence unit
Medical intelligence unit (Unnumbered : 2003)
Contents Immune risk phenotypes and associated parameters in very old humans : a review of findings in the Swedish NONA immune longitudinal study / Anders Wikby [and others] -- Scoring of immunological vigor : trial assessment of immunological status as a whole for elderly people and cancer patients / Katsuiku Hirokawa [and others] -- Remodelling of the CD8 T-cell compartment in the elderly : expression of NK associated receptors on T-cells is associated with the expansion of the effector memory subset / Inmaculada Gayoso [and others]
Telomeres, telomerase, and CD28 in human CD8 T-cells : effects on immunity during aging and HIV infection / Steven R. Fauce and Rita B. Effros -- A matter of life and death of T-lymphocytes in immunosenescence / Sudhir Gupta -- T-cell signalling, a complex process for T-cell activation compromised with aging : when membrane rafts can simplify everything / Tamas Fulop [and others] -- Immunosenescence, thymic involution and autoimmunity / Wayne A. Mitchell and Richard Aspinall
Autoimmune diseases, aging and the CD4+ lymphocyte : why does insulin-dependent diabetes mellitus start in youth, but rheumatoid arthritis mostly at older age? / Jacek M. Witkowski -- Role of chemokines and chemokine receptors in diseases of ageing / Erminia Mariani, Adriana Rita Mariani and Andrea Facchini -- The efficacy of vaccines to prevent infectious diseases in the elderly / Dietmar Herndler-Brandstetter and Beatrix Grubeck-Loebenstein -- Zinc and the altered immune system in the elderly / Hajo Haase and Lothar Rink
Zinc-binding proteins and immunosenescence : implications as biological and genetic markers / Eugenio Mocchegiani and Marco Malavolta -- Immunogenetics of aging / Elissaveta J. Naumova and Milena I. Ivanova -- The genetics of innate immunity and inflammation in ageing, age-related diseases and longevity / Calogero Caruso [and others] -- SELDI proteomics approach to identify proteins associated with T-cell clone senescence / Dawn J. Mazzatti [and others]
Summary Human immunosenescence contributes to morbidity and mortality in later life. The age-associated increasing incidence of cancer and cardiovascular disease plateaus at around 80 years of age in industrialised countries, but death due to infectious disease continues to increase up to 100 years of age and beyond. Understanding the reasons for age-associated alterations to protective immunity in the elderly would facilitate the development of interventions to reconstitute appropriate immune function, increase responsiveness to vaccination and extend healthspan. The majority of the papers collected in this volume therefore address not only the mechanisms responsible for immune ageing in humans but consider what might be accomplished to redress the erosion of immune competence with age
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Immune system -- Aging
Aging -- Immunological aspects.
Age factors in disease.
Longitudinal method.
Aging -- immunology
Immunity -- physiology
Age Factors
Disease Susceptibility -- immunology
Longevity -- immunology
Longitudinal Studies
T-Lymphocytes -- immunology
MEDICAL -- Immunology.
Biomédecine.
Sciences de la vie.
Longitudinal method
Age factors in disease
Aging -- Immunological aspects
Form Electronic book
Author Pawelec, G. (Graham)
LC no. 2007042878
ISBN 9780387768427
0387768424
6611954090
9786611954093