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E-book

Title Handbook of immunosenescence : basic understanding and clinical implications / Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec, editors
Edition Second edition
Published Cham, Switzerland : Springer, [2019]

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Description 1 online resource
Contents Methods and Models for Studying Immunosenescence -- Methods for studying human immunosenescence in tissues other than blood -- Mechanisms -- Receptors and Signal Transduction -- Clinical Relevance in Disease States -- Infection -- Modulation -- Nutrition
Summary Immunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question "can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?"
Notes Includes index
Online resource; title from digital title page (viewed on July 08, 2019)
Subject Immune system -- Aging
Genre/Form handbooks.
Handbooks and manuals
Handbooks and manuals.
Guides et manuels.
Form Electronic book
Author Fülöp, Tamas, 1953- editor.
Franceschi, Claudio, editor.
Hirokawa, Katsuiku, editor.
Pawelec, G. (Graham), editor.
ISBN 9783319993751
3319993755
9783319993744
3319993747