Introduction: The changing microbial environment, Darwinian medicine and the hygiene hypothesis -- The paleolithic disease-scape, the hygiene hypothesis, and the second epidemiological transition -- Immunoregulation by microbes and parasites in the control of allergy and autoimmunity -- Hepatitis A virus, TIM-1 and allergy -- Linking lifestyle with microbiota and risk of chronic inflammatory disorders -- Soil bacteria, nitrite and the skin -- The hygiene hypothesis and allergic disorders -- Multiple sclerosis -- Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths -- The hygiene hypothesis and Type 1 diabetes -- The hygiene hypothesis and affective and anxiety disorders -- Immune regulation in atherosclerosis and the hygiene hypothesis -- The 'delayed infection' (aka 'hygiene') hypothesis for childhood leukaemia -- Is there room for Darwinian medicine and the hygiene hypothesis in Alzheimer pathogenesis? -- Alternative and additional mechanisms to the hygiene hypothesis
Summary
Discusses the evidence for and against in the context of Darwinian medicine, which uses knowledge of evolution to cast light on human diseases. This book considers the broader implications of the hygiene hypothesis in areas of medicine
