| Description |
1 online resource |
| Contents |
Molecular Immunotoxicology; Contents; Preface; List of Contributors; Chapter 1 The Evolution of Immunotoxicology; 1.1 Introduction; 1.2 Immune-Mediated Environmental Lung Diseases; 1.3 Immunotoxic Drug Reactions; 1.4 Autoimmunity; 1.5 Immunosuppression; 1.6 Allergic Contact Dermatitis (ACD); 1.7 Summary; References; Chapter 2 Overview on the Mechanisms Underlying Chemical-Induced Immunotoxicity; 2.1 Introduction; 2.2 Mechanisms of Immunotoxicity; 2.2.1 Interference with Cellular Signaling; 2.2.1.1 Receptor-Mediated Immunotoxicity; 2.2.1.2 Non-receptor-Mediated Immunotoxicity |
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2.2.2 Adducts Formation and Role of ROS2.3 Conclusions; References; Chapter 3 Use of Toxicogenomics in Immunotoxicology; 3.1 Introduction; 3.2 Toxicogenomics; 3.2.1 Profiling Gene Expression; 3.2.2 Pathway Arrays; 3.2.3 Comparative Evaluation of Immunotoxicants; 3.2.4 miRNA and siRNA, Gene Expression Regulators; 3.2.5 mRNA Splicing; 3.2.6 RNA-Seq; 3.2.7 Proteomics; 3.2.8 Molecular Genomics; 3.2.9 Phenotypic Anchoring, Dose Response, Time Course; 3.3 Bioinformatics and Data Analysis; 3.3.1 Effect Markers and Machine Learning |
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3.4 Multiple Omic Approaches in the Evaluation of Immunosuppressive Compounds3.4.1 Multiple Omic Approaches in the Study of Hypersensitivity; 3.5 Summary and Conclusions; References; Chapter 4 Breakdown of the Molecular Processes Driving the Adverse Outcome Pathways (AOPs) of Skin and Respiratory Sensitization Induction in Humans Exposed to Xenobiotics and Proteins; 4.1 Introduction; 4.2 The AOP for Skin Sensitization; 4.3 The Molecular Processes in the MOA for Sensitization Induction; 4.3.1 Bioavailability: the Compound Acquires Access to the System |
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4.3.4 Dendritic Cell Activation: from Innate Responses to DC Maturation4.3.5 Dendritic Cell Migration: Translating the Message into Specific Actions; 4.3.6 T-Cell Priming and Proliferation: the Turning-Point between Sensitization and Effect; 4.4 Summary; References; Chapter 5 Chemical Allergen-Induced Skin Cell Activation; 5.1 Introduction; 5.2 Breaching the Barriers; 5.3 Role of the Extracellular Matrix in Skin Inflammation; 5.4 Cytoprotective Responses and Skin Inflammation; 5.5 Skin Dendritic Cells -- Tolerance versus Immunity; 5.6 DC Activation and Migration; 5.7 The Role of Danger Signals |
| Summary |
The first comprehensive reference on immunotoxicology using analyses based on molecular effects rather than on animal models. Following an introduction to immune system pathways and toxicity mechanisms from a systemic perspective, the main part of the book surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic e |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Immunotoxicology.
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Immunotoxins -- adverse effects
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Immune System Diseases -- chemically induced
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Industrial & Technical.
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Chemistry.
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SCIENCE.
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Immunotoxicology
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| Genre/Form |
Electronic books
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| Form |
Electronic book
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| Author |
Corsini, Emanuela
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Loveren, Henk van
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| ISBN |
9783527676972 |
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352767697X |
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9783527676965 |
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3527676961 |
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1322007438 |
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9781322007434 |
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9783527335190 |
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3527335196 |
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9783527676996 |
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3527676996 |
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9783527676989 |
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3527676988 |
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