| Description |
1 online resource (x, 180 pages) : illustrations |
| Series |
Endocrine development, 1421-7082 ; vol. 4 |
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Endocrine development ; vol. 4. 1421-7082
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| Contents |
Genetic regulation of forebrain and pituitary development / D.M. Martin, S.A. Camper -- Neural crest and pituitary development / H.C. Etchevers, C. Vincent, G. Couly -- Perspectives on the molecular basis of developmental defects in the human pituitary region / S. Amselem -- Growth hormone-releasing hormone receptors and pituitary development / G. Baumann -- Pituitary transcription factors, POU1F1 and PROP1 defects / R. Pfäffle [and others] -- Septo-optic dysplasia and related malformations / M.T. Dattani -- Magnetic resonance imaging of the hypothalamic-pituitary region in nontumoral hypopituitarism / I. Netchine, J. Léger, R. Rappaport -- Kallmann Syndrome : towards molecular pathogenesis / J.-P. Hardelin -- Genetic basis of hypothalamic-pituitary hypogonadism / F.P. Pralong -- Molecular pathology of corticotroph function / A.J.L. Clark, F.M. Swords -- Central diabetes insipidus / P. Czernichow |
| Summary |
In recent years dramatic progress has been made in understanding the pathophysiology of pituitary diseases by a combination of experimental studies, molecular genetics and clinical research. This book presents an updated overview of normal and pathological hypothalamic-pituitary development. Several chapters include experimental data and describe brain and facial defects associated with various conditions of pituitary insufficiency. A major part is devoted to the still increasing number of molecular and genetic defects which are responsible for various clinical presentations of pituitary insufficiency: diseases due to genetic defects of growth hormone, TSH, gonadotropins and corticotropin secretion are extensively described. These diseases present as metabolic (diabetes insipidus and adrenal insufficiency), growth and reproductive (including puberty) disorders. A distinct chapter emphasizes the contribution of a multidisciplinary comprehensive approach including the most recent molecular and genetic tools. Finally in most chapters an effort was made to address phenotypic and genotypic presentations in affected patients including valuable information provided by magnetic resonance imaging of the pituitary and brain. This book will help endocrinologists and pediatricians by providing unique models of genetic and developmental defects of the pituitary region which bear ultimate consequences on metabolic control, growth and reproduction |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Pituitary gland -- Pathophysiology
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Hypothalamus -- Pathophysiology
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Developmental endocrinology.
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Pituitary gland -- Growth
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Hypothalamus -- growth & development
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Hypothalamic Diseases -- genetics
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Pituitary Gland -- growth & development
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Developmental endocrinology
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Hypothalamus
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Hypophyse
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Entwicklung
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Neuroendokrines System
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Hypophysen-Zwischenhirn-System
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Aufsatzsammlung
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Hypophysenkrankheit
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| Form |
Electronic book
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| Author |
Rappaport, R. (Raphaël)
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Amselem, Serge
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S. Karger (Firm)
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| ISBN |
9783318007145 |
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3318007145 |
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