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Title Neurobiology of Huntington's disease : applications to drug discovery / edited by Donald C. Lo and Robert E. Hughes
Published Boca Raton : CRC Press/Taylor & Francis Group, 2011


Description 1 online resource : illustrations (some color)
Series Frontiers in neuroscience
Frontiers in neuroscience (Boca Raton, Fla.)
Contents Huntington's disease : clinical features and routes to therapy / Henry L. Paulson and Roger L. Albin -- Huntington's disease pathogenesis : mechanisms and pathways / Albert R. La Spada, Patrick Weydt, and Victor V. Pineda -- Protein interactions and target discovery in HD / John P. Miller and Robert E. Hughes -- Target validation for Huntington's disease / Seung P. Kwak, James K.T. Wang, and David S. Howland -- High-throughput and high-content screening for Huntington's disease therapeutics / Hemant Varma, Donald C. Lo, and Brent R. Stockwell -- Value of invertebrate genetics and biology to develop neuroprotective and preventive medicine in Huntington's disease / Christian Neri -- Mouse models for validating preclinical candidates for HD / X. William Yang and Michelle Gray -- Pharmaceutical development for HD / Richard J. Morse [and others] -- RNA and DNA-based therapies for Huntington's disease / Meghan Sass and Neil Aronin -- Recombinant intrabodies as molecular tools and potential therapeutics for Huntington's disease / Ali Khoshnan [and others] -- Biomarkers to enable the development of neuroprotective therapies for Huntington's disease / Steven M. Hersch and H. Diana Rosas -- Huntington disease : clinical experimental therapeutics / Ray Dorsey and Ira Shoulson
Summary "Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening; highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders; examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."-- Publisher's description
Notes Title from resource home page (NCBI Bookshelf, viewed Aug. 18, 2011)
Bibliography Includes bibliographical references
Notes English
Subject Huntington's disease -- Pathophysiology
Huntington's disease -- Molecular aspects
Huntington Disease -- physiopathology
Drug Discovery -- methods
Huntington Disease -- drug therapy
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Form Electronic book
Author Lo, Donald C., editor
Hughes, Robert E., Ph.D., editor.
LC no. 2010000178
ISBN 9781420008258