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Title Huntington disease / edited by Andrew S. Feigin and Karen E. Anderson
Published Amsterdam : Elsevier, [2017]


Description 1 online resource (xiii, 297 pages) : illustrations (some color)
Series Handbook of clinical neurology ; volume 144
Handbook of clinical neurology ; v. 144. 0072-9752
Contents Section 1: Basic science. Genetics of Huntington disease -- Mechanisms underlying neurodegeneration in Huntington disease: Applications to novel disease-modifying therapies -- Section 2: Clinical aspects. Epidemiology of Huntington disease -- Statistical modelling of Huntington disease onset -- The diagnosis and natural history of Huntington's disease -- Preclinical cognitive and behavioral changes in Huntington disease -- Preclinical motor manifestations of Huntington disease -- The highly anxious individual presenting for Huntington disease predictive genetic testing: the psychiatrist's role in assessment and counseling -- Reproductive options for Huntington disease families -- Genetic testing for Huntington disease -- Section 3: Treatment of Huntington disease. Medical treatment of behavioral manifestations of Huntington disease -- Medical management of motor manifestations of Huntington disease -- The role of rehabilitation therapy in Huntington disease -- Contemporary health care for Huntington disease -- The impact of Huntington disease on young people -- Making a measurable difference in advanced Huntington disease care -- Section 4: Experimental Therapeutics. New symptomatic therapies for Huntington disease -- Motor outcome measures in Huntington disease clinical trials -- Cognitive outcome measures in Huntington disease clinical drug trials -- Section 5: Biomarkers. Structural imaging in premanifest and manifest Huntington disease -- Functional imaging in Huntington disease
Summary "Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms. This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington's disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource"--Publisher's description
Bibliography Includes bibliographical references and index
Notes Online resource; title from electronic title page (ScienceDirect, viewed September 26, 2017)
Subject Huntington's disease.
Huntington Disease
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Huntington's disease
Form Electronic book
Author Feigin, Andrew S., editor
Anderson, Karen E. M.D., editor.
ISBN 9780128019030