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Title Streptococcus pneumoniae : molecular mechanisms of host-pathogen interactions / edited by Jeremy Brown, Sven Hammerschmidt, Carlos Orihuela
Published Amsterdam : Academic Press, [2015]


Description 1 online resource (xvii, 464 pages) : illustrations
Contents Front Cover; Streptococcus pneumoniae; Copyright Page; Contents; List of Contributors; Preface; A. Streptococcus pneumoniae Epidemiology and Vaccines; 1 Molecular Epidemiology of Streptococcus pneumoniae; Etiological Diagnosis of Pneumococcal Infections; Some Basic Concepts in Molecular Epidemiology; Serotyping and Molecular Typing of S. pneumoniae; Serotyping; Pulsed-Field Gel Electrophoresis; Multilocus Sequence Typing; Other Typing Methods; Whole Genome Sequencing; Clones of S. pneumoniae; References; 2 Antibiotic Resistance of Pneumococci; Introduction; Risk Factors for Resistance
880-01 Introduction of PCV Has Led to Direct and Indirect Protection Against Antimicrobial ResistanceConcluding Remarks; References; 3 Pneumococcal Vaccination and Consequences; Effect of the Vaccine on Pneumococcal Carriage; Effect of the Vaccine on the Disease; Impact of Conjugate Vaccines on Mucosal Infection; Effect of Conjugate Vaccines on IPD; Impact on Clinical Manifestations; Effect of PCV in Bacteremia and Meningitis; Effect of PCV in Pneumonia; Impact on Antimicrobial Resistance; Pneumococcal Conjugate Vaccination for Older Adults; Conclusion; References
880-01/(S Clinical Relevance of ResistanceDetection of Resistance; Mechanisms of Resistance; β-Lactam Resistance; Macrolide Resistance; Target Modification; Efflux Pumps; Dual Phenotype; Fluoroquinolone Resistance; Molecular Mechanisms of Fluoroquinolone Resistance; Mutations in QRDRs; Efflux Pump; Horizontal Gene Transfer and the Clonal Concept; Tetracycline Resistance; Rifampin Resistance; Chloramphenicol Resistance; Trimethoprim-Sulfamethoxazole Resistance; Ketolides Resistance; Oxazolidinone Resistance; Streptogramin Resistance; Role of Clones in Resistance; Vaccines and Resistance
4 Vaccine Potential of Pneumococcal ProteinsIntroduction; Next-Generation Pneumococcal Vaccine Candidates and Strategies; Pneumolysin; Choline-Binding Proteins; Pneumococcal Surface Protein A; Pneumococcal Surface Protein C; Autolysin (LytA); Pneumococcal Choline-Binding Protein; Lipoproteins; Pneumococcal Surface Antigen A; PiuA and PiaA; Other Lipoprotein Vaccine Candidates; Pht Proteins; Sortase-Dependent Surface Proteins and Other Secreted Proteins; Recently Characterized Protein Vaccine Candidates; PcsB and StkP; AliA and GlpO; Whole Cell Vaccines; Conclusions and Future Perspectives
Summary Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology. It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections. Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases
Bibliography Includes bibliographical references and index
Notes Vendor-supplied metadata
Subject Streptococcus pneumoniae.
Streptococcus pneumoniae
Host-Pathogen Interactions
Humans -- virology
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Streptococcus pneumoniae
Health & Biological Sciences.
Microbiology & Immunology.
Form Electronic book
Author Brown, Jeremy, 1964- editor.
Hammerschmidt, Sven, editor
Orihuela, Carlos (Carlos J.), editor.
ISBN 9780124114531