Limit search to available items
Book Cover

Title Human interphase chromosomes : biomedical aspects / Ivan Iourov, Svetlana Vorsanova, Yuri Yurov, editors
Edition Second edition
Published Cham, Switzerland : Springer, [2020]


Description 1 online resource (xii, 178 pages) : illustrations (some color)
Contents Human Interphase Cytogenomics -- Eukaryotic genome in three dimensions -- Analysis of cell and nucleus genome by Next-Generation Sequencing -- Interphase Chromosomes of the Human Brain -- Senescence and the Genome -- Unclassified Chromosome Abnormalities and Genome Behavior in Interphase -- Twenty-first century FISH: focus on interphase chromosomes -- Chromosome architecture studied by high resolution FISH-banding in three dimensionally preserved human interphase nuclei -- Chromosome-centric Look at the Genome
Summary This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology
Notes Edition statement from preface
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed March 16, 2021)
Subject Human cytogenetics.
Human chromosomes.
Chromosomes, Human -- genetics
Interphase -- genetics
Chromosomes, Human
Human chromosomes.
Human cytogenetics.
Form Electronic book
Author I︠U︡rov, Ivan I︠U︡rʹevich, editor.
Vorsanova, S. G. (Svetlana Grigorʹevna), editor.
I︠u︡rov, I︠u︡riĭ Borisovich, editor.
ISBN 9783030625320