| Description |
1 online resource (x, 300 pages) : illustrations |
| Series |
Novartis Foundation symposium ; 259 |
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Novartis Foundation symposium ; 259
|
| Contents |
Beyond the double helix : writing and reading the histone code / Yanming Wang, Wolfgang Fischle, Wang Cheung, Steven Jacobs, Sepideh Khorasanizadeh and C. David Allis -- The indexing potential of histone lysine methylation / Gunnar Schotta, Monika Lachner, Antoine H.F.M. Peters and Thomas Jenuwein -- A model for step-wise assembly of heterochromatin in yeast / Danesh Moazed, Adam D. Rudner, Julie Huang, Georg J. Hoppe and Jason C. Tanny -- H2B ubiquitylation and de-ubiquitylation in gene activation / Anastasia Wyce, Karl W. Henry and Shelley L. Berger -- Structural and chemical basis of histone acetylation / Ronen Marmorstein -- Phosphorylation and acetylation of histone H3 at inducible genes : two controversies revisited / Louis C. Mahadevan, Alison L. Clayton, Catherine A. Hazzalin and Stuart Thomson -- HDAC7 regulates apoptosis in developing thymocytes / Eric Verdin, Frank Dequiedt and Herb Kasler -- Dual roles of histone deacetylases in the control of cardiac growth / Timothy A. McKinsey and Eric N. Olson -- Chromatin modifications as clues to the regulation of antigen receptor assembly / David Ciccone and Marjorie Oettinger -- The HDAC complex and cytoskeleton / Jeffery J. Kovacs, Charlotte Hubbert and Tso-Pang Yao -- Tat acetylation : a regulatory switch between early and late phases in HIV transcription elongation / Melanie Ott, Alexander Dorr, Claudia Hetzer-Egger, Katrin Kaehlcke, Martina Schnolzer, Peter Henklein, Phil Cole, Ming-Ming Zhou and Eric Verdin -- Dynamics of the p53 acetylation pathway / Wei Gu, Jianyuan Luo, Chris L. Brooks, Anatoly Y. Nikolaev and Muyang Li -- Regulation of NF-[kappa]B action by reversible acetylation / Warner C. Greene and Lin-Feng Chen -- Reversal of gene silencing as a therapeutic target for cancer : roles for DNA methylation and its interdigitation with chromatin / Stephen B. Baylin -- Transcription regulation by histone deacetylases / Shaowen Wang, Yan Yan-Neale, Marija Zeremski and Dalia Cohen -- Molecular and cellular basis for the anti-proliferative effects of the HDAC inhibitor LAQ824 / Peter Atadja, Meier Hsu, Paul Kwon, Nancy Trogani, Kapil Bhalla and Stacy Remiszewski -- Histone deacetylase inhibitors : development as cancer therapy / Paul A. Marks, Victoria M. Richon, Wm Kevin Kelly, Judy H. Chiao and Thomas Miller |
| Summary |
A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation. This area of research opens up new and exciting possibilities for drug design, and so the final chapters in the book examine some of the potential applications in the treatment of various diseases |
| Analysis |
Cell and molecular biology |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Print version record |
| Subject |
Acetyltransferases -- metabolism.
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Histones -- metabolism.
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Acetylation.
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Histone Deacetylases -- genetics.
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Histone Deacetylases -- metabolism.
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Histones -- genetics.
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Transcription, Genetic.
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Acetylation.
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Chromatin -- Structure.
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Histone deacetylase.
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Histones.
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Proteins -- Chemical modification.
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Proteins -- Structure.
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| Genre/Form |
Congress.
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Conference papers and proceedings.
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| Form |
Electronic book
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| Author |
Bock, Gregory.
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Goode, Jamie.
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Novartis Foundation.
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Symposium on Reversible Protein Acetylation (2003 London, England)
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| ISBN |
0470862610 (print edition) |
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0470862629 (electronic bk.) |
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0470862637 (electronic bk.) |
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9780470862612 (print edition) |
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9780470862629 (electronic bk.) |
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9780470862636 (electronic bk.) |
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