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Author Aptsiauri, Natalia.

Title MHC class I antigens in malignant cells : immune escape and response to immunotherapy / Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera
Published New York, NY : Springer, [2013]
©2013
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Description 1 online resource
Series SpringerBriefs in cancer research ; 6
SpringerBriefs in cancer research ; 6
Contents Overview of MHC Class I Antigens -- HLA Class I Expression in Human Cancer -- MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns -- Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression -- Conclusions
Summary Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develo
Analysis Medicine
Oncology
Immunology
Biomedicine
Cancer Research
Molecular Medicine
Bibliography Includes bibliographical references
Subject Cancer -- Immunological aspects.
Major histocompatibility complex.
HLA histocompatibility antigens.
Histocompatibility Antigens Class II.
Major Histocompatibility Complex.
Neoplasms -- immunology.
Form Electronic book
Author Garcia-Lora, Angel Miguel.
Cabrera, Teresa (María Teresa Cabrera Castillo)
LC no. 2013931654
ISBN 9781461465430 (electronic bk.)
1461465435 (electronic bk.)
1299693784
9781299693784